Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24105268 | 0.89 | OPRM1 (0.33) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL29320617 | 0.83 | OPRM1 (0.30) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL26260561 | 0.79 | ALDH1A1 (0.31) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL24099533 | 0.76 | LMNA (0.44) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL29771571 | 0.76 | LMNA (0.44) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL23182622 | 0.76 | LMNA (0.44) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL23458475 | 0.76 | LMNA (0.44) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28638822 | 0.75 | LMNA (0.43) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL28638820 | 0.75 | LMNA (0.43) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL23486058 | 0.73 | ALDH1A1 (0.32) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238257-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | SANOFI (FR) | 2024-07-18 | — | — | US | disclosed |
| US-20230233534-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | NEUROCRINE BIOSCIENCES, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230233534-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | CYP21A2, NR5A1, HSD3B1 | OPRM1 3048/4885OPRD1 4110/4885OPRK1 3021/4885 |
| US-20240238257-A1 | SYNTHETIC METHODS FOR PREPARATION OF 4-(2-CHLORO-4-METHOXY-5-METHYLPHENYL)-N-[(1S)-2-CYCLOPROPYL-1-(3-FLUORO-4-METHYLPHENYL)ETHYL]-5-METHYL-N-PROP-2-YNYL-1,3-THIAZOL-2-AMINE | CYP21A2, NR5A1, HSD3B1 | OPRM1 2453/4885OPRD1 3810/4885OPRK1 2548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.