SCHEMBL25873147

SCHEMBL25873147

O=C(NNS(=O)(=O)c1ccc([N+](=O)[O-])cc1)Nc1ccccc1

nearest known ligand 0.76

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.76
CA2 P00918 3/20 0.76
CA9 Q16790 3/20 0.76
CA1 P00915 2/20 0.76
GAA P10253 7/20 0.73
POLB P06746 2/20 0.73
SMN1; SMN2 Q16637 2/20 0.70
ALDH1A1 P00352 2/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
MAPT P10636 1/20 0.57
HPGD P15428 1/20 0.57
KMT2A Q03164 2/20 0.56
LMNA P02545 1/20 0.56
MEN1 O00255 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28696236 0.85 CA12 (0.77) CA12CA2CA9CA1GAA
Diphenylurea SCHEMBL27302793 0.82 MEN1 (0.81) GAAPOLBSMN1; SMN2L3MBTL1MAPT
SCHEMBL25870930 0.81 CA12 (0.72) CA12CA2CA9CA1GAA
SCHEMBL26104435 0.81 GAA (0.65) CA12CA2CA9CA1GAA
SCHEMBL11055960 0.80 MEN1 (0.85) GAAPOLBSMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL22124552 0.80 CA2 (0.72) CA12CA2CA9CA1GAA
SCHEMBL7776322 0.79 FLT1 (0.64) CA12CA2CA9CA1GAA
SCHEMBL7776164 0.79 FLT1 (0.64) CA12CA2CA9CA1GAA
SCHEMBL23069044 0.77 MEN1 (0.73) GAAPOLBSMN1; SMN2ALDH1A1L3MBTL1
SCHEMBL19472794 0.77 ALDH1A1 (0.71) CA2CA9CA1GAAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND AUTOTAC INC. (KR) 2023-06-08 US disclosed
WO-2023074936-A1 BIFUNCTIONAL COMPOUND USING UBR BOX DOMAIN-BINDING LIGAND 주식회사 오토텍바이오 2023-05-04 WO disclosed
CN-115715285-A Compounds as UBR box domain ligands 奧土择破利悟 2023-02-24 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND UBR4, UBQLN2, UBTF CA12 4586/4885CA2 4852/4885CA9 4699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.