SCHEMBL25870930

SCHEMBL25870930

Nc1ccc(S(=O)(=O)NNC(=O)Nc2ccccc2)cc1

nearest known ligand 0.72

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CA12 O43570 10/20 0.72
CA1 P00915 10/20 0.72
CA2 P00918 10/20 0.72
CA9 Q16790 10/20 0.72
GAA P10253 3/20 0.68
LMNA P02545 2/20 0.68
SMN1; SMN2 Q16637 1/20 0.68
TDP1 Q9NUW8 1/20 0.68
KMT2A Q03164 2/20 0.57
MEN1 O00255 1/20 0.55
CYP2C9 P11712 1/20 0.55
RECQL P46063 1/20 0.55
ALDH1A1 P00352 1/20 0.52
HPGD P15428 1/20 0.52
NPC1 O15118 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28696236 0.89 CA12 (0.77) CA12CA1CA2CA9GAA
SCHEMBL25870936 0.86 CA12 (0.54) CA12CA1CA2CA9GAA
SCHEMBL25873147 0.81 CA12 (0.76) CA12CA1CA2CA9GAA
SCHEMBL20567504 0.79 LMNA (0.62) CA1CA2CA9GAALMNA
SCHEMBL11532705 0.76 BCAT1 (0.71) CA12CA1CA2CA9GAA
SCHEMBL546369 0.76 RAB9A (0.83) CA12CA1CA2CA9LMNA
Hydrochloric Acid SCHEMBL29163198 0.76 TDP1 (0.68) CA1CA2CA9GAALMNA
SCHEMBL6396355 0.75 KAT6A (0.78) GAALMNASMN1; SMN2TDP1KMT2A
SCHEMBL25248605 0.75 ALDH1A1 (0.74) CA12CA1CA2CA9GAA
SCHEMBL9063965 0.74 BCAT1 (0.62) CA12CA1CA2CA9GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023074936-A1 BIFUNCTIONAL COMPOUND USING UBR BOX DOMAIN-BINDING LIGAND 주식회사 오토텍바이오 2023-05-04 WO claimed
EP-4144722-A1 COMPOUND AS UBR BOX DOMAIN LIGAND Autotac Inc. (KR) 2023-03-08 EP claimed
CN-115715285-A Compounds as UBR box domain ligands 奧土择破利悟 2023-02-24 CN claimed
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND AUTOTAC INC. (KR) 2023-06-08 US disclosed
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND AUTOTAC INC. (KR) 2023-06-08 US disclosed
WO-2023074936-A1 BIFUNCTIONAL COMPOUND USING UBR BOX DOMAIN-BINDING LIGAND 주식회사 오토텍바이오 2023-05-04 WO disclosed
EP-4144722-A1 COMPOUND AS UBR BOX DOMAIN LIGAND Autotac Inc. (KR) 2023-03-08 EP disclosed
CN-115715285-A Compounds as UBR box domain ligands 奧土择破利悟 2023-02-24 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174470-A1 COMPOUND AS A UBR BOX DOMAIN LIGAND UBR4, UBQLN2, UBTF CA12 4586/4885CA1 4715/4885CA2 4852/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.