SCHEMBL25875884

SCHEMBL25875884

COc1cc2c(O)cc3c(c2cc1OC)-c1ccc(C#N)cc1C3(CCC(F)(F)F)CCC(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 6/20 0.35
PDK2 Q15119 1/20 0.34
PRKDC P78527 1/20 0.32
CTDSP1 Q9GZU7 1/20 0.32
CETP P11597 1/20 0.31
AR P10275 2/20 0.31
NR3C1 P04150 1/20 0.30
PGR P06401 1/20 0.30
NR3C2 P08235 1/20 0.30
CYP19A1 P11511 2/20 0.30
BACE1 P56817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25836787 0.87 ALK (0.34) ALKPRKDCCTDSP1ARCYP19A1
SCHEMBL25875887 0.85 KCNH2 (0.35) CETP
SCHEMBL25875873 0.81 IDO1 (0.36) PDK2BACE1
SCHEMBL1009801 0.80 ALK (0.43) ALKAR
SCHEMBL25836793 0.75 KCNH2 (0.35)
SCHEMBL25875866 0.74 PTPN1 (0.35) PDK2
SCHEMBL25876918 0.73 PDK2 (0.36) PDK2
SCHEMBL25876421 0.73 PDK2 (0.37) PDK2
SCHEMBL1812178 0.72 CHEK1 (0.37) ALKPDK2PRKDCCTDSP1AR
SCHEMBL25836778 0.71 TDO2 (0.36) PDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023140186-A1 PHOTOCHROMIC COMPOUND, NAPHTHOL DERIVATIVE, CURABLE COMPOSITION, OPTICAL ARTICLE, LENS, AND EYEGLASSES 株式会社トクヤマ 2023-07-27 WO disclosed