Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.45 |
| ▸ | CTSV | O60911 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27678664 | 0.87 | PTGER1 (0.51) | PTGER1MCL1FFAR4PTPN1LMNA | |
| SCHEMBL14882664 | 0.85 | CTSV (0.52) | PTGER1MCL1BRD4FFAR4LMNA | |
| SCHEMBL30141095 | 0.84 | FOLH1 (0.52) | PTGER1MCL1MRGPRX4FOLH1CTSV | |
| SCHEMBL6761323 | 0.84 | FOLH1 (0.52) | PTGER1MCL1MRGPRX4FOLH1CTSV | |
| SCHEMBL24983696 | 0.84 | LMNA (0.54) | MCL1BRD4PTPN1LMNAHPGD | |
| SCHEMBL27720163 | 0.83 | CTSV (0.51) | BRD4LMNAHPGDMRGPRX4FOLH1 | |
| SCHEMBL24140919 | 0.83 | MRGPRX4 (0.51) | LMNAHPGDMRGPRX4FOLH1CTSV | |
| SCHEMBL12379065 | 0.82 | PTGER1 (0.53) | PTGER1MCL1FFAR4PTPN1LMNA | |
| SCHEMBL9617336 | 0.82 | MAPT (0.52) | PTGER1MCL1BRD4LMNAHPGD | |
| SCHEMBL28322588 | 0.80 | MRGPRX4 (0.48) | PTGER1MCL1FFAR4PTPN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | PTGER1 1918/4885MCL1 1660/4885BRD4 1515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.