Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | RXRB | P28702 | 1/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 9/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 5/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24140930 | 0.87 | PTPN1 (0.54) | PTPN1PTPN6PTPN2LMNAHPGD | |
| SCHEMBL25885262 | 0.85 | ALDH1A1 (0.46) | RXRARXRBRXRGLMNAHPGD | |
| SCHEMBL9393494 | 0.84 | LMNA (0.59) | PTPN1LMNAHPGDMAOAMAOB | |
| SCHEMBL3954569 | 0.79 | RXRA (0.52) | RXRARXRBRXRGLMNAHPGD | |
| SCHEMBL25022830 | 0.78 | LMNA (0.52) | PTPN1LMNAHPGDMAOAMAOB | |
| SCHEMBL4045055 | 0.76 | MAOA (0.57) | LMNAMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL9811349 | 0.75 | MAOA (0.52) | LMNAMAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL18002600 | 0.75 | MAOA (0.60) | MAOAMAOBKDM4EALDH1A1MRGPRX4 | |
| SCHEMBL13907556 | 0.73 | ERN1 (0.51) | LMNAMAOAMAOBAPPKDM4E | |
| SCHEMBL1180820 | 0.73 | MAOA (0.56) | LMNAMAOAMAOBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2023-07-27 | — | — | US | disclosed |
| WO-2021263079-A1 | TREX1 INHIBITORS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. (US) | 2021-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230234943-A1 | TREX1 INHIBITORS AND USES THEREOF | FEN1, ERCC4, DCLRE1B | RXRA 1048/4885RXRB 1117/4885RXRG 1043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.