Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591473 | 0.82 | ALDH1A1 (0.49) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL2592282 | 0.81 | CYP1A2 (0.54) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29723380 | 0.81 | RAB9A (0.54) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL576677 | 0.81 | RAB9A (0.54) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4212164 | 0.80 | KDM4E (0.61) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6130015 | 0.79 | CYP1A2 (0.63) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29001733 | 0.76 | RAB9A (0.51) | KDM4ERAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL7400760 | 0.75 | KDM4E (0.56) | KDM4ERAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL30753694 | 0.74 | TP53 (0.56) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16920972 | 0.73 | RAB9A (0.69) | RAB9ANPC1ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |