Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592282 | 0.85 | CYP1A2 (0.54) | ALDH1A1CYP1A2TSHRRAB9ALMNA | |
| SCHEMBL13610341 | 0.83 | RAB9A (0.45) | ALDH1A1CYP1A2TSHRRAB9AKCNA5 | |
| SCHEMBL6130015 | 0.83 | CYP1A2 (0.63) | ALDH1A1CYP1A2TSHRRAB9ALMNA | |
| SCHEMBL2589313 | 0.82 | KDM4E (0.56) | ALDH1A1CYP1A2TSHRRAB9ALMNA | |
| SCHEMBL3233668 | 0.78 | L3MBTL1 (0.65) | RAB9AKCNA5SMN1; SMN2L3MBTL1 | |
| SCHEMBL4635750 | 0.77 | RAB9A (0.53) | ALDH1A1CYP1A2TSHRRAB9ALMNA | |
| SCHEMBL487139 | 0.77 | ALDH1A1 (0.55) | ALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL8867729 | 0.77 | CYP1A2 (0.56) | ALDH1A1CYP1A2RAB9AKCNA5LMNA | |
| SCHEMBL5641219 | 0.76 | RAB9A (0.47) | ALDH1A1RAB9AKCNA5LMNANPC1 | |
| SCHEMBL31058796 | 0.75 | ALDH1A1 (0.59) | ALDH1A1CYP1A2TSHRRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |