Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2574754 | 0.91 | HCAR3 (0.35) | MEN1KMT2AALDH1A1GAAL3MBTL1 | |
| SCHEMBL2576665 | 0.89 | ALDH1A1 (0.39) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2532967 | 0.86 | ALDH1A1 (0.43) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2568952 | 0.86 | CRBN (0.39) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2536690 | 0.83 | ALDH1A1 (0.46) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2578929 | 0.82 | VNN1 (0.38) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2535519 | 0.82 | MAPK14 (0.47) | RAB9ANPC1MEN1KMT2AKDM4E | |
| SCHEMBL2527678 | 0.82 | GRM4 (0.39) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2527848 | 0.81 | ALDH1A1 (0.42) | SMN1; SMN2RAB9ANPC1MEN1KMT2A | |
| SCHEMBL2534017 | 0.81 | ALDH1A1 (0.42) | SMN1; SMN2RAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558449-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011128251-A1 | NOVEL 3,3-DIMETHYL TETRAHYDROQUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2011-10-20 | — | — | WO | disclosed |