Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19393068 | 0.81 | PLAU (0.50) | PLAUMTNR1AMTNR1BHTR1AMAOA | |
| SCHEMBL14815575 | 0.78 | ANPEP (0.49) | PLAUMTNR1AMTNR1BHTR1AMAOA | |
| SCHEMBL5028027 | 0.73 | PLAU (0.50) | PLAUMTNR1AMTNR1BHTR1AMAOA | |
| SCHEMBL15147099 | 0.70 | PLAU (0.56) | PLAUMTNR1AMTNR1BHTR1AMAOA | |
| SCHEMBL29978110 | 0.70 | PLAU (0.56) | PLAUMTNR1AMTNR1BHTR1AMAOA | |
| SCHEMBL598142 | 0.70 | PLAU (0.56) | PLAUMTNR1AMTNR1BHTR1AMAOA | |
| SCHEMBL823055 | 0.69 | MTNR1A (0.61) | PLAUMTNR1AMTNR1BMAOAMAOB | |
| SCHEMBL823057 | 0.69 | MTNR1A (0.61) | PLAUMTNR1AMTNR1BMAOAMAOB | |
| SCHEMBL29599386 | 0.69 | MTNR1A (0.61) | PLAUMTNR1AMTNR1BMAOAMAOB | |
| SCHEMBL4606877 | 0.69 | MTNR1A (0.61) | PLAUMTNR1AMTNR1BMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219465-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme Inc (US) | 2023-08-02 | — | — | EP | disclosed |