Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | DRD4 | P21917 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.56 |
| ▸ | CA1 | P00915 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29599386 | 1.00 | MTNR1A (0.61) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL4606877 | 1.00 | MTNR1A (0.61) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL823055 | 1.00 | MTNR1A (0.61) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL7430755 | 0.98 | MTNR1A (0.59) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL1026136 | 0.98 | MTNR1A (0.59) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL714537 | 0.84 | SIGMAR1 (0.53) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| Hydrochloric Acid SCHEMBL1027335 | 0.82 | SIGMAR1 (0.52) | MTNR1AMTNR1BDRD2DRD4DRD3 | |
| SCHEMBL7838746 | 0.79 | MTNR1A (0.61) | MTNR1AMTNR1BMAOAMAOBGRIN2B | |
| SCHEMBL459537 | 0.79 | GRIN2B (0.65) | MTNR1AMTNR1BMAOAMAOBGRIN2B | |
| SCHEMBL25909439 | 0.79 | GRIN2B (0.56) | MTNR1AMTNR1BMAOAMAOBGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8053603-B2 | Tetralone-based monoamine reuptake inhibitors | SUNOVION PHARMACEUTICALS INC. (US) | 2011-11-08 | — | — | US | disclosed |
| US-7459460-B2 | Trisubstituted heteroaromatic compounds as calcium sensing receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-02 | — | — | US | disclosed |
| US-20070197588-A1 | Tetralone-based monoamine reuptake inhibitors | SEPRACOR INC. (US) | 2007-08-23 | — | — | US | disclosed |
| EP-0817767-B1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-05-24 | — | — | EP | disclosed |
| US-6008219-A | Bicyclic amine derivatives and their use as anti-psychotic agents | SMITHKLINE BEECH P.L.C. (GB) | 1999-12-28 | — | — | US | disclosed |
| EP-0817767-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030333-A1 | BICYCLIC AMINE DERIVATIVES AND THEIR USE AS ANTI-PSYCHOTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1996-10-03 | — | — | WO | disclosed |
| WO-1992007821-A1 | DIASTEREOISOMERS OF BICYCLO-SUBSTITUTED PHENYLACETONITRILE DERIVATIVES | G.D. SEARLE & CO. (US) | 1992-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197588-A1 | Tetralone-based monoamine reuptake inhibitors | SLC18A2, SLC6A2, SLC6A3 | MTNR1A 496/4885MTNR1B 416/4885DRD2 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.