Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | PNMT | P11086 | 1/20 | 0.44 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19393068 | 0.79 | PLAU (0.50) | PLAUANPEPGRIN2BMTNR1AMTNR1B | |
| SCHEMBL14815575 | 0.76 | ANPEP (0.49) | PLAUANPEPGRIN2BMTNR1AMTNR1B | |
| SCHEMBL14039949 | 0.76 | OPRK1 (0.34) | PNMT | |
| SCHEMBL31197411 | 0.74 | DRD2 (0.48) | GRIN2BCYP19A1 | |
| SCHEMBL25900511 | 0.73 | PLAU (0.44) | PLAUANPEPGRIN2BMTNR1AMTNR1B | |
| SCHEMBL29080091 | 0.71 | PLAU (0.56) | PLAUANPEPGRIN2BMTNR1AMTNR1B | |
| SCHEMBL17151026 | 0.71 | PLAU (0.56) | PLAUANPEPGRIN2BMTNR1AMTNR1B | |
| SCHEMBL10062425 | 0.71 | PLAU (0.46) | PLAUANPEPGRIN2BMTNR1AMTNR1B | |
| SCHEMBL28185295 | 0.71 | CYP1A2 (0.45) | PNMTANPEPCYP19A1MAOA | |
| SCHEMBL4443332 | 0.71 | PLAU (0.46) | PLAUPNMTANPEPGRIN2BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118496196-A | Preparation method of alpha-trifluoromethyl aryl ketone compound | 嘉兴职业技术学院 | 2024-08-16 | — | — | CN | disclosed |
| WO-2015040424-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS | VERNALIS (R&D) LIMITED (GB) | 2015-03-26 | — | — | WO | disclosed |
| EP-2450358-A1 | Fused, tricyclic sulfonamide inhibitors of gamma secretase | Elan Pharmaceuticals Inc. (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-1274700-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | Pharmacia Corporation (US) | 2003-01-15 | — | — | EP | disclosed |
| WO-2001049675-A1 | DIHYDROBENZOPYRANS, DIHYDROBENZOTHIOPYRANS, AND TETRAHYDROQUINOLINES FOR THE TREATMENT OF COX-2-MEDIATED DISORDERS | PHARMACIA CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |