Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | LDHB | P07195 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855072 | 0.84 | GABRA1 (0.47) | TRPA1PTGS1GABRA1GABRB2CACNA1C | |
| SCHEMBL25906319 | 0.80 | TRPA1 (0.55) | TRPA1PTGS1CACNA1CBACE1LDHA | |
| SCHEMBL22888328 | 0.78 | HDAC4 (0.49) | TRPA1PTGS1GABRA1GABRB2CACNA1C | |
| SCHEMBL6574657 | 0.74 | BACE1 (0.47) | PTGS1BACE1RPS6KA3PON1PTGS2 | |
| SCHEMBL6346880 | 0.73 | GABRA1 (0.73) | TRPA1PTGS1GABRA1GABRB2CACNA1C | |
| SCHEMBL23050226 | 0.73 | LMNA (0.63) | TRPA1PTGS1CACNA1CLDHALDHB | |
| SCHEMBL22319169 | 0.73 | METAP2 (0.50) | TRPA1PTGS1GABRA1GABRB2CACNA1C | |
| SCHEMBL15313776 | 0.73 | CA1 (0.47) | TRPA1PTGS1GABRA1GABRB2LDHA | |
| SCHEMBL23754720 | 0.73 | BACE1 (0.46) | TRPA1PTGS1CACNA1CBACE1LMNA | |
| SCHEMBL16581358 | 0.72 | TRPA1 (0.44) | TRPA1PTGS1CACNA1CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | AAAS, PROC, AADAC | TRPA1 4291/4885PTGS1 1090/4885GABRA1 3069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.