Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | CASP1 | P29466 | 2/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1799185 | 0.82 | ALOX5 (0.43) | ALOX5TP53ALDH1A1POLBKDM4E | |
| SCHEMBL11911410 | 0.78 | — | — | |
| SCHEMBL5517928 | 0.77 | ALOX5 (0.44) | ALOX5TP53ALDH1A1POLBKDM4E | |
| SCHEMBL1078857 | 0.76 | ALOX5 (0.39) | ALOX5TP53ALDH1A1POLBKDM4E | |
| SCHEMBL18244837 | 0.73 | — | — | |
| SCHEMBL28050574 | 0.73 | — | — | |
| SCHEMBL1048506 | 0.73 | — | — | |
| SCHEMBL7109005 | 0.73 | — | — | |
| SCHEMBL12394781 | 0.73 | ALOX5 (0.54) | ALOX5TP53 | |
| SCHEMBL5886532 | 0.73 | ALOX5 (0.39) | ALOX5TP53MEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250129063-A1 | BENZOTHIAZOLE COMPOUNDS AS VHL LIGANDS | GENENTECH, INC. (US) | 2025-04-24 | — | — | US | disclosed |
| WO-2025076285-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | DELPHIA THERAPEUTICS, INC. (US) | 2025-04-10 | — | — | WO | disclosed |
| CN-119677735-A | Benzothiazole compounds as VHL ligands | 基因泰克公司 | 2025-03-21 | — | — | CN | disclosed |
| EP-4522270-A1 | BENZOTHIAZOLE COMPOUNDS AS VHL LIGANDS | Genentech Inc. (US) | 2025-03-19 | — | — | EP | disclosed |
| US-20230391766-A1 | 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXY-N-(BENZYL)PYRROLIDIN E-2-CARBOXAMIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA AND CANCER | GENENTECH, INC. (US) | 2023-12-07 | — | — | US | disclosed |
| WO-2023220237-A1 | BENZOTHIAZOLE COMPOUNDS AS VHL LIGANDS | GENENTECH, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220237-A1 | BENZOTHIAZOLE COMPOUNDS AS VHL LIGANDS | GENENTECH, INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| EP-4244218-A1 | 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXY-N-(BENZYL)PYRROLIDIN E-2-CARBOXAMIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA AND CANCER | Genentech, Inc. (US) | 2023-09-20 | — | — | EP | disclosed |
| CN-116783183-A | 1- (2- (4-cyclopropyl-1H-1, 2, 3-triazol-1-yl) acetyl) -4-hydroxy-N- (benzyl) pyrrolidine-2-carboxamide derivatives as VHL inhibitors for the treatment of anemia and cancer | 基因泰克公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2023104976-A1 | SMALL MOLECULE INHIBITORS OF INTERFERON GAMMA SIGNALING | INSTITUT CURIE (FR) | 2023-06-15 | — | — | WO | disclosed |
| WO-2015123365-A1 | COMPOSITIONS AND METHODS USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE | MITOKININ LLC (US) | 2015-08-20 | — | — | WO | disclosed |
| WO-2015123365-A1 | COMPOSITIONS AND METHODS USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE | MITOKININ LLC (US) | 2015-08-20 | — | — | WO | disclosed |
| WO-2014152115-A1 | N-,C-DISUBSTITUTED AZOLES FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2014-09-25 | — | — | WO | disclosed |
| US-20140274689-A1 | N-,C-DISUBSTITUTED AZOLES AND COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | MONSANTO TECHNOLOGY LLC (US) | 2014-09-18 | — | — | US | disclosed |
| US-8722910-B2 | Diyne compositions | EVOLVA AG (CH) | 2014-05-13 | — | — | US | disclosed |
| US-8722910-B2 | Diyne compositions | EVOLVA AG (CH) | 2014-05-13 | — | — | US | disclosed |
| EP-2563769-A1 | DIYNE COMPOSITIONS | EVOLVA AG (CH) | 2013-03-06 | — | — | EP | disclosed |
| US-20120196822-A1 | Diyne Compositions | EVOLVA AG (CH) | 2012-08-02 | — | — | US | disclosed |
| WO-2011134538-A1 | DIYNE COMPOSITIONS | EVOLVA LTD (CH) | 2011-11-03 | — | — | WO | disclosed |
| WO-2011006061-A1 | DIYNE COMPOSITIONS | EVOLVA SA (CH) | 2011-01-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140274689-A1 | N-,C-DISUBSTITUTED AZOLES AND COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODE PESTS | CYCS, DNPH1, DDT | ALOX5 756/4885TP53 4267/4885ALDH1A1 2730/4885 |
| US-20230391766-A1 | 1-(2-(4-CYCLOPROPYL-1H-1,2,3-TRIAZOL-1-YL)ACETYL)-4-HYDROXY-N-(BENZYL)PYRROLIDIN E-2-CARBOXAMIDE DERIVATIVES AS VHL INHIBITORS FOR THE TREATMENT OF ANEMIA AND CANCER | VHL, HIF1AN, EGLN2 | ALOX5 3365/4885TP53 24/4885ALDH1A1 1058/4885 |
| US-20250129063-A1 | BENZOTHIAZOLE COMPOUNDS AS VHL LIGANDS | VHL, BRCA1, GLS | ALOX5 3983/4885TP53 4/4885ALDH1A1 2210/4885 |
| US-20120196822-A1 | Diyne Compositions | OSR1, ERG28, OSBPL3 | ALOX5 845/4885TP53 2689/4885ALDH1A1 3833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.