Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 5/20 | 0.35 |
| ▸ | HTR2A | P28223 | 5/20 | 0.35 |
| ▸ | HTR7 | P34969 | 5/20 | 0.35 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | DRD3 | P35462 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25314455 | 0.91 | IP6K1 (0.40) | HTR1AHTR2AHTR7HTR6SMN1; SMN2 | |
| SCHEMBL30507370 | 0.91 | IP6K1 (0.40) | HTR1AHTR2AHTR7HTR6SMN1; SMN2 | |
| SCHEMBL25312899 | 0.89 | ALK (0.39) | MAPT | |
| SCHEMBL25932252 | 0.87 | HTR1A (0.37) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL25317378 | 0.84 | HRH3 (0.44) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL26048605 | 0.80 | DRD2 (0.36) | HTR1AHTR2AHTR7DRD3DRD2 | |
| SCHEMBL25932861 | 0.80 | KDM4E (0.41) | HTR1AHTR2AHTR7HTR6DRD3 | |
| SCHEMBL25908655 | 0.80 | GPR119 (0.41) | HTR1AHTR2AHTR7HTR6DRD3 | |
| SCHEMBL25912010 | 0.80 | DRD3 (0.37) | GRIN2DGRIN3BMAPTGRIN1GRIN2A | |
| SCHEMBL26044329 | 0.79 | PGR (0.39) | ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |