Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 6/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 2/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | CDK7 | P50613 | 2/20 | 0.34 |
| ▸ | CCNH | P51946 | 2/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25913006 | 0.88 | CSF1R (0.40) | P2RX3IRAK4BRAFRIOK2 | |
| SCHEMBL25912751 | 0.81 | MAPK8 (0.39) | IRAK4BRAFMAPK8MAPK6GSK3B | |
| SCHEMBL25913590 | 0.80 | CSF1R (0.43) | BRAFRIOK2 | |
| SCHEMBL25912909 | 0.77 | PDGFRB (0.50) | BRAFKDRRIOK2 | |
| SCHEMBL25912755 | 0.74 | MAPK8 (0.42) | IRAK4MAPK8CDK2MAPK6GSK3B | |
| SCHEMBL25912887 | 0.74 | P2RX3 (0.37) | P2RX3BRAFKDRABL1DYRK1A | |
| SCHEMBL25913221 | 0.73 | P2RX3 (0.38) | P2RX3IRAK4BRAFKDRDYRK1A | |
| SCHEMBL25910292 | 0.72 | CSF1R (0.57) | P2RX3BRAFKDR | |
| SCHEMBL25912707 | 0.72 | P2RX3 (0.40) | P2RX3BRAFKDRRIOK2DYRK1A | |
| SCHEMBL25912842 | 0.72 | PDGFRB (0.52) | P2RX3BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |