Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.33 |
| ▸ | LPL | P06858 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.31 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.31 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25916642 | 0.85 | LIPG (0.47) | MAPTLIPGLPLROCK1DGAT1 | |
| SCHEMBL25916640 | 0.81 | ROCK1 (0.38) | MAPTLIPGLPLSIGMAR1PDK1 | |
| SCHEMBL13830608 | 0.70 | LIPG (0.59) | LIPGLPLDGAT1BRD4 | |
| SCHEMBL14696435 | 0.69 | LIPG (0.45) | LIPGLPL | |
| SCHEMBL29253468 | 0.66 | QDPR (0.44) | MAPTHRH3 | |
| SCHEMBL13663767 | 0.65 | MAPT (0.40) | MAPTSIGMAR1PDK1PDK2PDK3 | |
| SCHEMBL13663770 | 0.65 | MAPT (0.40) | MAPTSIGMAR1PDK1PDK2PDK3 | |
| SCHEMBL31453994 | 0.64 | LIPG (0.50) | MAPTLIPGLPL | |
| SCHEMBL31453989 | 0.64 | LIPG (0.50) | MAPTLIPGLPL | |
| SCHEMBL17010798 | 0.64 | LIPG (0.44) | LIPGLPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139379-A1 | MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE (ROCK) | REDX PHARMA PLC (GB) | 2023-07-27 | — | — | WO | disclosed |