Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.34 |
| ▸ | LPL | P06858 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | P4HB | P07237 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25916642 | 0.84 | LIPG (0.47) | ROCK1LIPGLPLMAPTDGAT1 | |
| SCHEMBL25916638 | 0.81 | MAPT (0.34) | ROCK1LIPGLPLMAPTDGAT1 | |
| SCHEMBL25916636 | 0.69 | HTR2A (0.39) | LIPGLPL | |
| SCHEMBL623701 | 0.69 | LIPG (0.62) | ROCK1LIPGLPLPRMT5WDR77 | |
| SCHEMBL27026510 | 0.67 | LPL (0.50) | ROCK1LIPGLPLPRMT5WDR77 | |
| SCHEMBL13535660 | 0.67 | PRMT5 (0.42) | ROCK1LIPGLPLPRMT5WDR77 | |
| SCHEMBL25916637 | 0.66 | ROCK1 (0.33) | ROCK1LIPGLPL | |
| SCHEMBL20287950 | 0.66 | PRMT5 (0.55) | LIPGLPLPRMT5WDR77 | |
| SCHEMBL12117403 | 0.66 | LIPG (0.49) | ROCK1LIPGLPLPRMT5WDR77 | |
| SCHEMBL22256237 | 0.66 | LPL (0.45) | ROCK1LIPGLPLPRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139379-A1 | MODULATORS OF RHO-ASSOCIATED PROTEIN KINASE (ROCK) | REDX PHARMA PLC (GB) | 2023-07-27 | — | — | WO | disclosed |