Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 9/20 | 0.38 |
| ▸ | GPR183 | P32249 | 2/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25323130 | 0.89 | PDE2A (0.37) | PDE2AGPR183CHRNA7KCNH2EPHX2 | |
| SCHEMBL25328280 | 0.76 | NTRK1 (0.35) | PDE2AMGLLP2RX7BTK | |
| SCHEMBL25325112 | 0.76 | TEAD1 (0.44) | JAK2JAK1TYK2JAK3MGLL | |
| SCHEMBL25324066 | 0.74 | P2RX7 (0.39) | GPR183EPHX2P2RX7 | |
| SCHEMBL30553285 | 0.73 | FAAH (0.36) | MGLLP2RX7 | |
| SCHEMBL25325576 | 0.73 | FAAH (0.36) | MGLLP2RX7 | |
| SCHEMBL25325835 | 0.72 | MGLL (0.37) | PDE2AJAK2JAK1TYK2JAK3 | |
| SCHEMBL25322265 | 0.72 | POLB (0.39) | PDE2AMGLL | |
| SCHEMBL25322558 | 0.72 | BCHE (0.41) | PDE2AEPHX2JAK2JAK1TYK2 | |
| SCHEMBL25324564 | 0.72 | ENPP2 (0.38) | PDE2AJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144160-A1 | NEW HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-08-03 | — | — | WO | disclosed |