SCHEMBL259178

SCHEMBL259178

NCC(=O)NC(Cc1c[nH]cn1)C(=O)NCC(=O)O

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
SLC15A2 Q16348 1/20 0.38
PTGS1 P23219 1/20 0.36
GSTK1 Q9Y2Q3 1/20 0.36
GLO1 Q04760 2/20 0.32
MME P08473 7/20 0.32
EGLN1 Q9GZT9 3/20 0.31
ALDH1A1 P00352 2/20 0.31
ACE P12821 2/20 0.31
HPGD P15428 1/20 0.31
MAPK1 P28482 1/20 0.31
HSD17B10 Q99714 1/20 0.31
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31
ECE1 P42892 1/20 0.31
BLM P54132 1/20 0.31
NPEPPS P55786 1/20 0.31
KMT2A Q03164 1/20 0.31
EGLN3 Q9H6Z9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL259179 1.00 SLC15A2 (0.38) SLC15A2PTGS1GSTK1GLO1MME
SCHEMBL31323969 0.94 SLC15A2 (0.34) SLC15A2PTGS1GSTK1GLO1
SCHEMBL29630686 0.91 OPRD1 (0.38) SLC15A2
SCHEMBL30441904 0.91 SLC15A2 (0.37) SLC15A2PTGS1GSTK1
SCHEMBL29793344 0.91 PTGS1 (0.37) SLC15A2PTGS1GSTK1GLO1
SCHEMBL20397507 0.91 SLC15A2 (0.41) SLC15A2
SCHEMBL20397438 0.91 SLC15A2 (0.41) SLC15A2
SCHEMBL29793386 0.91 PTGS1 (0.39) PTGS1GSTK1GLO1
SCHEMBL29031269 0.91 PTGS1 (0.39) PTGS1GSTK1GLO1
SCHEMBL29793028 0.90 PTGS1 (0.36) PTGS1GSTK1GLO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8865857-B2 Medical device with predefined activated cellular integration SOFRADIM PRODUCTION (FR) 2014-10-21 US claimed
US-4732155-A Implantable chemoattractant system THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 1988-03-22 US claimed
US-20170267628-A1 ISOMER-SELECTIVE SYNTHESIS OF METHANOFULLERENES NANO-C, INC. 2017-09-21 US disclosed
US-9586989-B1 Non-toxic skin cancer therapy with copper peptides SKIN BIOLOGY, INC. (US) 2017-03-07 US disclosed
US-8865857-B2 Medical device with predefined activated cellular integration SOFRADIM PRODUCTION (FR) 2014-10-21 US disclosed
CN-102387792-B Solid preparation LINTEC CORP 2013-08-14 CN disclosed
US-20130143976-A1 MEDICAL DEVICE WITH PREDEFINED ACTIVATED CELLULAR INTEGRATION SOFRADIM PRODUCTION (FR) 2013-06-06 US disclosed
EP-2588153-A2 MEDICAL DEVICE WITH PREDEFINED ACTIVATED CELLULAR INTEGRATION Sofradim Production (FR) 2013-05-08 EP disclosed
CN-102387792-A Solid preparation LINTEC CORP 2012-03-21 CN disclosed
US-20120034276-A1 SOLID PREPARATION ASKA PHARMACEUTICAL CO., LTD. 2012-02-09 US disclosed
EP-2412366-A1 SOLID PREPARATION LINTEC Corporation (JP) 2012-02-01 EP disclosed
EP-0884389-A1 Enzyme participating in C-terminal amidation, and method of preparing same and use thereof SHISEIDO COMPANY LIMITED (JP) 1998-12-16 EP disclosed
EP-0882768-A2 Method for producing of phthalocyanine compound NIPPON SHOKUBAI CO., LTD. (JP) 1998-12-09 EP disclosed
EP-0438600-B1 ENZYMES WHICH PARTICIPATE IN C-TERMINAL AMIDATION, AND PRODUCTION AND USE THEREOF SHISEIDO CO LTD (JP) 1996-02-07 EP disclosed
EP-0666318-A1 Enzyme participating in c-terminal amidation, and method of preparing same and use thereof SHISEIDO COMPANY LIMITED (JP) 1995-08-09 EP disclosed
US-5354675-A Amidation of glycine SHISEIDO COMPANY LTD. (JP) 1994-10-11 US disclosed
EP-0447547-B1 C-TERMINUS AMIDATION ENZYME COMPOSITION, PROCESS FOR ITS PREPARATION AND ITS USE SHISEIDO CO LTD (JP) 1994-07-27 EP disclosed
EP-0447547-A1 C-TERMINUS AMIDATION ENZYME COMPOSITION, PROCESS FOR ITS PREPARATION AND ITS USE SHISEIDO COMPANY LIMITED (JP) 1991-09-25 EP disclosed
EP-0438600-A1 ENZYMES WHICH PARTICIPATE IN C-TERMINAL AMIDATION, AND PRODUCTION AND USE THEREOF SHISEIDO COMPANY LIMITED (JP) 1991-07-31 EP disclosed
US-4732155-A Implantable chemoattractant system THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 1988-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130143976-A1 MEDICAL DEVICE WITH PREDEFINED ACTIVATED CELLULAR INTEGRATION CCL2, MIF, C3AR1 SLC15A2 3528/4885PTGS1 731/4885GSTK1 678/4885
US-20170267628-A1 ISOMER-SELECTIVE SYNTHESIS OF METHANOFULLERENES GABRB1, GABRB3, GABRB2 SLC15A2 3912/4885PTGS1 3865/4885GSTK1 2950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.