Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15834447 | 0.83 | ALDH1A1 (0.38) | ALDH1A1MAPK1RAPGEF4CYP2A6ALOX15 | |
| SCHEMBL30168170 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MAPK1TAS1R3TAS1R1CCR2 | |
| SCHEMBL2781542 | 0.81 | ALDH1A1 (0.42) | ALDH1A1MAPK1TAS1R3TAS1R1CCR2 | |
| SCHEMBL20801053 | 0.81 | ALDH1A1 (0.36) | ALDH1A1MAPK1RAPGEF4CYP2A6ALOX15 | |
| SCHEMBL3107273 | 0.80 | ALDH1A1 (0.38) | ALDH1A1MAPK1CCR2SLC6A4HRH3 | |
| SCHEMBL8587844 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPK1TAS1R3TAS1R1CCR2 | |
| SCHEMBL21415078 | 0.79 | ALDH1A1 (0.35) | ALDH1A1MAPK1RAPGEF4CYP2A6NPC1 | |
| SCHEMBL3376143 | 0.77 | MAPT (0.46) | ALDH1A1RAPGEF4CYP2A6NPC1RAB9A | |
| SCHEMBL2874105 | 0.74 | ALDH1A1 (0.40) | ALDH1A1MAPK1CCR2SLC6A4NPC1 | |
| SCHEMBL5946318 | 0.74 | KDM4E (0.41) | ALDH1A1MAPK1SLC6A4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021951-A1 | WDR5-MYC INHIBITORS | VANDERBILT UNIVERSITY (US) | 2021-02-04 | — | — | WO | disclosed |
| EP-3656781-A1 | A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES | The Scripps Research Institute (US) | 2020-05-27 | — | — | EP | disclosed |
| US-10626138-B2 | Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides | THE SCRIPPS RESEARCH INSTITUTE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT OF HEALTH AND HUMAN SERVICES (DHHS) (US) | 2020-04-21 | — | — | US | disclosed |
| US-20200040027-A1 | A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES | THE SCRIPPS RESEARCH INSTITUTE | 2020-02-06 | — | — | US | disclosed |
| US-9670166-B2 | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9670166-B2 | Substituted bicyclic dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-06-06 | — | — | US | disclosed |
| EP-2953943-B1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2017-04-12 | — | — | EP | disclosed |
| US-20160340319-A1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2016-11-24 | — | — | US | disclosed |
| US-20160340319-A1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | BOEHRINGER INGELHEIM INT (DE) | 2016-11-24 | — | — | US | disclosed |
| US-20160168187-A1 | A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES | Synthorx, Inc. (US) | 2016-06-16 | — | — | US | disclosed |
| US-5804532-A | REACTING A BENZOYL ISOXAZOLE WITH A BASE | RHONE-POULENC AGRICULTURE LIMITED (GB) | 1998-09-08 | — | — | US | disclosed |
| US-5747424-A | HEATING AN AROMATIC DIKETONE WITH A SALT OF HYDROXYLAMINE IN A SOLVENT | RHONE-POULENC AGRICULTURE LTD. (GB) | 1998-05-05 | — | — | US | disclosed |
| US-5656573-A | Herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-08-12 | — | — | US | disclosed |
| US-5650533-A | Intermediates to herbicidal 4-substituted isoxazoles | RHONE-POULENC AGRICULTURE LTD. (GB) | 1997-07-22 | — | — | US | disclosed |
| EP-0487357-B1 | 4 Benzoyl isoxazole derivatives | RHONE POULENC AGRICULTURE (GB) | 1997-07-02 | — | — | EP | disclosed |
| EP-0527036-B1 | 4-Benzoylisoxazole derivatives and their use as herbicides | RHONE POULENC AGRICULTURE (GB) | 1996-11-06 | — | — | EP | disclosed |
| EP-0496631-B1 | 2-Cyano-1,3-dione herbicides | RHONE POULENC AGRICULTURE (GB) | 1995-06-07 | — | — | EP | disclosed |
| EP-0527036-A1 | 4-Benzoylisoxazole derivatives and their use as herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1993-02-10 | — | — | EP | disclosed |
| EP-0496631-A1 | 2-Cyano-1,3-dione herbicides | RHONE-POULENC AGRICULTURE LTD. (GB) | 1992-07-29 | — | — | EP | disclosed |
| EP-0487357-A1 | 4 Benzoyl isoxazole derivatives | RHONE-POULENC AGRICULTURE LTD. (GB) | 1992-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160168187-A1 | A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES | RNGTT, POLM, POLRMT | ALDH1A1 2175/4885MAPK1 4269/4885TAS1R3 4198/4885 |
| US-20160340319-A1 | SUBSTITUTED BICYCLIC DIHYDROPYRIMIDINONES AND THEIR USE AS INHIBITORS OF NEUTROPHIL ELASTASE ACTIVITY | SERPINB1, ELANE, MPO | ALDH1A1 109/4885MAPK1 1402/4885TAS1R3 2394/4885 |
| US-20200040027-A1 | A METHOD FOR THE SITE-SPECIFIC ENZYMATIC LABELLING OF NUCLEIC ACIDS IN VITRO BY INCORPORATION OF UNNATURAL NUCLEOTIDES | RNGTT, POLM, POLRMT | ALDH1A1 2175/4885MAPK1 4269/4885TAS1R3 4198/4885 |
| US-10626138-B2 | Method for the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides | RNGTT, POLM, POLRMT | ALDH1A1 2129/4885MAPK1 4395/4885TAS1R3 4163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.