Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.49 |
| ▸ | NOS2 | P35228 | 4/20 | 0.49 |
| ▸ | NOS3 | P29474 | 2/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | MBD2 | Q9UBB5 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25323166 | 1.00 | NOS1 (0.49) | NOS1NOS2NOS3CHRNB4CHRNA3 | |
| SCHEMBL25323163 | 1.00 | NOS1 (0.49) | NOS1NOS2NOS3CHRNB4CHRNA3 | |
| Trifluoroacetic Acid SCHEMBL25325870 | 0.91 | NOS3 (0.41) | NOS1NOS2NOS3CHRNB4CHRNA3 | |
| SCHEMBL25323286 | 0.82 | NOS3 (0.35) | NOS1NOS2NOS3CHRNB4CHRNA3 | |
| SCHEMBL20835498 | 0.72 | CHRNB4 (0.46) | NOS1NOS2NOS3CHRNB4CHRNA3 | |
| SCHEMBL5889295 | 0.71 | NOS1 (0.54) | NOS1NOS2NOS3CHRNB4CHRNA3 | |
| Hydrochloric Acid SCHEMBL8871069 | 0.68 | CHRNB4 (0.41) | CHRNB4CHRNA3SMN1; SMN2NPC1MAPT | |
| SCHEMBL24367106 | 0.66 | CHRNB4 (0.42) | NOS1NOS2NOS3CHRNB4CHRNA3 | |
| SCHEMBL28949545 | 0.65 | CHRNB4 (0.31) | CHRNB4CHRNA3 | |
| SCHEMBL22546622 | 0.64 | NISCH (0.41) | NOS1NOS2NOS3CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |