Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SDCBP | O00560 | 1/20 | 0.38 |
| ▸ | SDC2 | P34741 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25920284 | 0.93 | NPC1 (0.43) | NPC1RAB9AMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL25920245 | 0.92 | ALOX15 (0.43) | MAPK1SMN1; SMN2SDCBPSDC2MAPT | |
| SCHEMBL25918412 | 0.89 | NPC1 (0.50) | NPC1RAB9AKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL25920286 | 0.85 | NTSR1 (0.45) | MAPK1SMN1; SMN2SDCBPSDC2MAPT | |
| SCHEMBL25919933 | 0.84 | CYP11B1 (0.46) | NPC1RAB9AMAPK1KMT2ASMN1; SMN2 | |
| SCHEMBL25918494 | 0.83 | NPC1 (0.45) | NPC1RAB9AKMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL25330885 | 0.81 | MAPK1 (0.39) | MAPK1SDCBPSDC2 | |
| SCHEMBL30477327 | 0.81 | MAPK1 (0.39) | MAPK1SDCBPSDC2 | |
| SCHEMBL25918414 | 0.81 | ALOX15 (0.50) | SMN1; SMN2SDCBPSDC2ALDH1A1MAPT | |
| SCHEMBL25920054 | 0.80 | NPC1 (0.45) | NPC1RAB9AMAPK1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023132606-A1 | NOVEL ISOINDOLINONE DERIVATIVE COMPOUNDS AS CASPASE INHIBITORS | 주식회사 이노보테라퓨틱스 | 2023-07-13 | — | — | WO | disclosed |