Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.35 |
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25922298 | 0.75 | PRPS1 (0.41) | HSD11B1GRM2ESR1P2RX7KCNH2 | |
| SCHEMBL25924821 | 0.73 | ESR1 (0.35) | HSD11B1ESR1P2RX7 | |
| SCHEMBL25923960 | 0.70 | HCAR3 (0.32) | HCAR3 | |
| SCHEMBL11407750 | 0.69 | HCAR3 (0.55) | HCAR3GRM2ALDH1A1CYP1A2SLC9A1 | |
| SCHEMBL25315277 | 0.69 | AR (0.38) | HSD11B1GRM2ESR1KCNH2ALDH1A1 | |
| SCHEMBL25923938 | 0.69 | AR (0.38) | HSD11B1GRM2ESR1KCNH2ALDH1A1 | |
| SCHEMBL30506949 | 0.69 | AR (0.38) | HSD11B1GRM2ESR1KCNH2ALDH1A1 | |
| SCHEMBL29693662 | 0.64 | SLC9A1 (0.40) | HSD11B1GRM2P2RX7ALDH1A1CYP1A2 | |
| SCHEMBL31698451 | 0.63 | ESR1 (0.41) | HCAR3HSD11B1ESR1P2RX7PRPS1 | |
| SCHEMBL20806166 | 0.61 | HCAR3 (0.43) | HCAR3ALDH1A1SMN1; SMN2SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |