Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25923933 | 0.73 | HCAR3 (0.38) | ESR1P2RX7HSD11B1 | |
| SCHEMBL25922298 | 0.69 | PRPS1 (0.41) | ESR1P2RX7HSD11B1POLB | |
| SCHEMBL13115635 | 0.67 | KMO (0.43) | ESR1MDM2POLB | |
| SCHEMBL21725659 | 0.66 | HTR2A (0.42) | ESR1P2RX7POLBMAPK1 | |
| Piperidine SCHEMBL2959417 | 0.65 | TRPA1 (0.40) | P2RX7TRPA1MDM2 | |
| SCHEMBL23717737 | 0.65 | CYP19A1 (0.40) | MDM2 | |
| SCHEMBL23717652 | 0.62 | P2RX7 (0.42) | P2RX7POLB | |
| SCHEMBL31698874 | 0.61 | CYP1A2 (0.37) | ESR1TRPA1 | |
| SCHEMBL21725617 | 0.60 | HSD11B1 (0.39) | HSD11B1MDM2 | |
| SCHEMBL21725615 | 0.60 | ESR1 (0.39) | ESR1P2RX7HSD11B1MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023141432-A2 | APOL1 INHIBITORS AND METHODS OF USE | MAZE THERAPEUTICS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |