Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 2/20 | 0.44 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29179859 | 0.92 | ENPP2 (0.48) | ENPP2ATXN2L3MBTL1MAPTMAPK1 | |
| SCHEMBL25819451 | 0.91 | ENPP2 (0.43) | ENPP2ATXN2L3MBTL1MAPTMAPK1 | |
| SCHEMBL25335140 | 0.88 | ENPP2 (0.47) | ENPP2ATXN2DPP4KCNH2DPP7 | |
| SCHEMBL30135872 | 0.86 | YAP1 (0.47) | ENPP2ATXN2L3MBTL1MAPTMAPK1 | |
| SCHEMBL30965581 | 0.85 | DRD2 (0.47) | ENPP2ATXN2L3MBTL1MAPTMAPK1 | |
| SCHEMBL8328356 | 0.84 | ENPP2 (0.52) | ENPP2ATXN2L3MBTL1NPSR1MEN1 | |
| SCHEMBL30121231 | 0.83 | L3MBTL1 (0.51) | L3MBTL1MAPTMAPK1NPSR1NTSR1 | |
| SCHEMBL25935334 | 0.82 | ENPP2 (0.47) | ENPP2ATXN2MEN1KMT2ADPP4 | |
| SCHEMBL25935391 | 0.82 | L3MBTL1 (0.49) | L3MBTL1MAPTMAPK1NPSR1NTSR1 | |
| SCHEMBL23249973 | 0.82 | MEN1 (0.47) | NPSR1MEN1KMT2AKDM1AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | UPPTHERA, INC. (KR) | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242541-A1 | NOVEL PLK1 DEGRADATION INDUCING COMPOUND | PLK1, BUB1B, BUB1 | ENPP2 1565/4885ATXN2 2262/4885L3MBTL1 964/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.