SCHEMBL2593638

SCHEMBL2593638

CC(C)(C)c1cc(N)cc(N)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.55
GABRA1 P14867 1/20 0.46
GABRB2 P47870 1/20 0.46
MAPT P10636 3/20 0.43
GAA P10253 2/20 0.43
KDM4E B2RXH2 1/20 0.43
ALDH1A1 P00352 5/20 0.41
NPC1 O15118 3/20 0.41
RAB9A P51151 3/20 0.41
HTR1D P28221 2/20 0.41
HPGD P15428 2/20 0.41
MAPK1 P28482 2/20 0.41
RECQL P46063 2/20 0.41
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
PKM P14618 1/20 0.41
TSHR P16473 3/20 0.40
HTR1B P28222 1/20 0.37
ALOX15 P16050 1/20 0.35
HSD17B10 Q99714 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL112570 0.94 POLB (0.55) POLBGABRA1GABRB2MAPTGAA
Iodide SCHEMBL32662609 0.91 POLB (0.52) POLBGABRA1GABRB2MAPTGAA
Hydrochloric Acid SCHEMBL23530441 0.91 POLB (0.59) POLBGABRA1GABRB2MAPTGAA
SCHEMBL30720010 0.84 MAPT (0.52) POLBGABRA1GABRB2MAPTGAA
SCHEMBL9290257 0.84 ALDH1A1 (0.60) POLBGABRA1GABRB2MAPTGAA
SCHEMBL1530352 0.82 POLB (0.44) POLBGABRA1GABRB2MAPTGAA
SCHEMBL15934253 0.82 GABRA1 (0.68) POLBGABRA1GABRB2MAPTGAA
SCHEMBL14200010 0.82 MAPK1 (0.46) POLBGABRA1GABRB2MAPTGAA
SCHEMBL21327977 0.82 POLB (0.44) POLBGABRA1GABRB2MAPTGAA
SCHEMBL3783775 0.82 CYP3A4 (0.55) POLBGABRA1GABRB2MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5399655-A Acid-labile poly(amic acetal ester) E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-03-21 US claimed
EP-0344594-B1 THERMOPLASTIC AROMATIC COPOLYETHERAMIDE, PROCESS FOR ITS PREPARATION AND ITS USE TO PRODUCE MOLDED ARTICLES HOECHST AKTIENGESELLSCHAFT (DE) 1993-09-08 EP claimed
EP-0557985-A1 Preparation of aromatic polyamides from CO, aromatic diamine and di(trifluoro methane sulfonate) EASTMAN CHEMICAL COMPANY (US) 1993-09-01 EP claimed
EP-0557987-A1 Preparation of aromatic poly(imide-amide)s from co, primary diamine and di(trifluoro methane sulfonate)containing phthalimide group EASTMAN KODAK COMPANY (US) 1993-09-01 EP claimed
EP-0557984-A2 Method for the preparation of aromatic polyimides EASTMAN CHEMICAL COMPANY (US) 1993-09-01 EP claimed
US-5216118-A Preparation of aromatic polyimides from CO, primary diamine and bis (halo aromatic carboxylic acid ester) EASTMAN KODAK COMPANY (US) 1993-06-01 US claimed
US-5214123-A Metal-mediated carbonylation and coupling of diamine and phthalimide ring-containing di/trifluoromethanesulfonate/ compound in solvent with platinum, palladium or nickel catalyst EASTMAN KODAK COMPANY (US) 1993-05-25 US claimed
US-5210175-A Catalyst of platinum, palladium or nickel EASTMAN KODAK COMPANY (US) 1993-05-11 US claimed
US-5104946-A For heat resistant low dielectric coatings OCCIDENTAL CHEMICAL CORPORATION (US) 1992-04-14 US claimed
EP-0459386-A1 Preparation of polyamides EASTMAN KODAK COMPANY (US) 1991-12-04 EP claimed
EP-0438751-A2 Solutions of polyimidesiloxanes in butyrolactone OCCIDENTAL CHEMICAL CORPORATION (US) 1991-07-31 EP claimed
US-5003037-A Films for protective coatings for dielectrics, electronics AMOCO CORPORATION (US) 1991-03-26 US claimed
US-4992527-A Heat resistance, protective coatings, electronics AMOCO CORPORATION (US) 1991-02-12 US claimed
US-4975521-A SOLUBLE, FILM FORMING AROMATIC POLYMER MADE FROM DIAMINE AND DIACID AMOCO CORPORATION (US) 1990-12-04 US claimed
US-4973659-A HEAR RESISTANT FILMS, FIBERS, COMPOSITES AMOCO CORPORATION (US) 1990-11-27 US claimed
US-4968780-A SOLUBLE IN N-METHYLPYRROLIDONE, HIGH GLASS TRANSITION TEMPERATURE, HEAT RESISTANT FILMS, FIBERS AND COMPOSITES AMOCO CORPORATION (US) 1990-11-06 US claimed
US-4966955-A Aromatic copolyether amide which can be processed as a thermoplastic, process for its preparation, and its use for the production of molding HOECHST AKTIENGESELLSCHAFT (DE) 1990-10-30 US claimed
US-4946934-A Useful for fiber making, coatings and films AMOCO CORPORATION (US) 1990-08-07 US claimed
EP-0344594-A1 Thermoplastic aromatic copolyetheramide, process for its preparation and its use to produce molded articles HOECHST AKTIENGESELLSCHAFT (DE) 1989-12-06 EP claimed
JP-2060934-A None JP disclosed
JP-5345822-A None JP disclosed
US-20260116867-A1 PROTEOLYSIS TARGETING CHIMERAS FOR HUMAN PREGNANE X RECEPTOR AND FOR DEGRADATION OF GSPT1 ST JUDE CHILDRENS RES HOSPITAL (US) 2026-04-30 US disclosed
US-20250282736-A1 SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR ST JUDE CHILDRENS RES HOSPITAL (US) 2025-09-11 US disclosed
CN-118834227-A Organic compound, application thereof and organic electroluminescent device using same 北京鼎材科技有限公司 2024-10-25 CN disclosed
CN-118005662-A Organic compound and application thereof, and organic electroluminescent device comprising organic compound 北京鼎材科技有限公司 2024-05-10 CN disclosed
WO-2023205807-A2 PROTEOLYSIS TARGETING CHIMERAS FOR HUMAN PREGNANE X RECEPTOR AND FOR DEGRADATION OF GSPT1 ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2023-10-26 WO disclosed
WO-2023205807-A2 PROTEOLYSIS TARGETING CHIMERAS FOR HUMAN PREGNANE X RECEPTOR AND FOR DEGRADATION OF GSPT1 ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2023-10-26 WO disclosed
WO-2023205344-A1 SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2023-10-26 WO disclosed
WO-2023205344-A1 SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2023-10-26 WO disclosed
WO-2023277604-A1 NOVEL COMPOUND FOR CAPPING LAYER, AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME 주식회사 동진쎄미켐 2023-01-05 WO disclosed
US-20210292436-A1 Methods of Inhibiting MASP-2 for the Treatment and/or Prevention of Coronavirus-induced Acute Respiratory Distress Syndrome OMEROS CORPORATION 2021-09-23 US disclosed
US-20210179612-A1 MASP-2 INHIBITORS AND METHODS OF USE OMEROS CORPORATION 2021-06-17 US disclosed
EP-2981535-B1 UREA DERIVATIVES USEFUL AS KINASE INHIBITORS TOPIVERT PHARMA LTD (GB) 2020-12-16 EP disclosed
EP-3394059-B1 1-(3-TERT-BUTYL-PHENYL)-3-(4-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YLOXY)-1,2,3,4-TETRAHYDRO- NAPHTHALEN-1-YL)-UREA DERIVATIVES AND THEIR USE AS P38 MAPK INHIBITORS CHIESI FARM SPA (IT) 2020-11-25 EP disclosed
US-10435361-B2 Kinase inhibitors TOPIVERT PHARMA LIMITED (GB) 2019-10-08 US disclosed
EP-3394059-A1 1-(3-TERT-BUTYL-PHENYL)-3-(4-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YLOXY)-1,2,3,4-TETRAHYDRO- NAPHTHALEN-1-YL)-UREA DERIVATIVES AND THEIR USE AS P38 MAPK INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2018-10-31 EP disclosed
US-10100050-B2 Kinase inhibitors CHIESI FARMACEUTICI S.P.A. (IT) 2018-10-16 US disclosed
CN-105246884-B Urea derivative as kinase inhibitor 瑞斯比维特有限公司 2018-05-22 CN disclosed
US-20180044288-A1 KINASE INHIBITORS OXULAR ACQUISITIONS LIMITED (GB) 2018-02-15 US disclosed
US-9790174-B2 Kinase inhibitors RESPIVERT LIMITED (GB) 2017-10-17 US disclosed
EP-2569081-B1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PROD & CHEM (US) 2017-08-23 EP disclosed
WO-2017108737-A1 1-(3-TERT-BUTYL-PHENYL)-3-(4-([1,2,4]TRIAZOLO[4,3-A]PYRIDIN-6-YLOXY)-1,2,3,4-TETRAHYDRO- NAPHTHALEN-1-YL)-UREA DERIVATIVES AND THEIR USE AS P38 MAPK INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2017-06-29 WO disclosed
US-20170183345-A1 KINASE INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2017-06-29 US disclosed
US-20160376232-A1 KINASE INHIBITORS OXULAR ACQUISITIONS LIMITED (GB) 2016-12-29 US disclosed
US-9481648-B2 Kinase inhibitors RESPIVERT LIMITED (GB) 2016-11-01 US disclosed
EP-2981535-A1 UREA DERIVATIVES USEFUL AS KINASE INHIBITORS Respivert Limited (GB) 2016-02-10 EP disclosed
CN-105246884-A Urea derivatives useful as kinase inhibitors RESPIVERT LTD 2016-01-13 CN disclosed
US-20150166483-A1 KINASE INHIBITORS RESPIVERT LTD (GB) 2015-06-18 US disclosed
US-8926733-B2 Polymers, polymer membranes and methods of producing the same AIR PRODUCTS AND CHEMICALS, INC. (US) 2015-01-06 US disclosed
WO-2014162126-A1 UREA DERIVATIVES USEFUL AS KINASE INHIBITORS RESPIVERT LIMITED (GB) 2014-10-09 WO disclosed
US-20140296208-A1 KINASE INHIBITORS TOPIVERT PHARMA LIMITED (GB) 2014-10-02 US disclosed
WO-2014118092-A2 DYE COMPOSITION COMPRISING AT LEAST ONE PARTICULAR LIPOPHILIC META-PHENYLENEDIAMINE COUPLER IN A MEDIUM RICH IN FATTY SUBSTANCES, PROCESSES AND DEVICES L'OREAL (FR) 2014-08-07 WO disclosed
EP-2569081-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME Air Products and Chemicals, Inc. (US) 2013-03-20 EP disclosed
US-20130047844-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2013-02-28 US disclosed
WO-2011143530-A1 POLYMERS, POLYMER MEMBRANES AND METHODS OF PRODUCING THE SAME AIR PRODUCTS AND CHEMICALS, INC. (US) 2011-11-17 WO disclosed
WO-2008089034-A2 CYTOKINE INHIBITORS KEMIA, INC. (US) 2008-07-24 WO disclosed
WO-2008089034-A2 CYTOKINE INHIBITORS KEMIA, INC. (US) 2008-07-24 WO disclosed
EP-0448248-B1 Process for making thick multilayers of polyimide TEXAS A & M UNIV SYS (US) 2002-06-26 EP disclosed
US-5516875-A POLYAMIDES ESTERIFIED WITH VINYL ETHERS, PHOTOACID CATALYZED CLEAVAGE OF THE ACID LABILE ESTERS, IMIDATION E. I. DU PONT DE NEMOURS AND COMPANY (US) 1996-05-14 US disclosed
EP-0601063-B1 FLUORINE-CONTAINING DIAMINES, POLYAMIDES, AND POLYIMIDES DU PONT (US) 1995-10-18 EP disclosed
EP-0446032-B1 Wet-etch process and composition AMOCO CORP (US) 1995-05-24 EP disclosed
US-5399655-A Acid-labile poly(amic acetal ester) E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-03-21 US disclosed
US-5399460-A Aminoacrylated polyimide E. I. DU PONT DE NEMOURS AND COMPANY (US) 1995-03-21 US disclosed
WO-1995004305-A1 PHOTOSENSITIVE FLUORINATED POLY(AMIC ACID) AMINOACRYLATE SALT E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-02-09 WO disclosed
EP-0603339-A1 POLYIMIDE COPOLYMERS CONTAINING 3,3',4,4'-TETRACARBOXYBIPHENYL DIANHYDRIDE (BPDA) MOIETIES AMOCO CORPORATION (US) 1994-06-29 EP disclosed
US-5322917-A Fluorine-containing diamines polyamides, and polyimides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-06-21 US disclosed
EP-0601063-A1 FLUORINE-CONTAINING DIAMINES, POLYAMIDES, AND POLYIMIDES. DU PONT (US) 1994-06-15 EP disclosed
US-5304626-A Chemical resistance AMOCO CORPORATION (US) 1994-04-19 US disclosed
US-5302489-A Patterning a photoresist E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-04-12 US disclosed
US-5286841-A Fluorine-containing diamines, polyamides, and polyimides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-02-15 US disclosed
JP-H05345822-A SOLUTION OF POLYIMIDESILOXANE IN BUTYROLACTONE OCCIDENTAL CHEM CORP 1993-12-27 JP disclosed
US-5268193-A Coating solution of polyamic acid on substrate; curing AMOCO CORPORATION (US) 1993-12-07 US disclosed
EP-0344594-B1 THERMOPLASTIC AROMATIC COPOLYETHERAMIDE, PROCESS FOR ITS PREPARATION AND ITS USE TO PRODUCE MOLDED ARTICLES HOECHST AKTIENGESELLSCHAFT (DE) 1993-09-08 EP disclosed
EP-0557985-A1 Preparation of aromatic polyamides from CO, aromatic diamine and di(trifluoro methane sulfonate) EASTMAN CHEMICAL COMPANY (US) 1993-09-01 EP disclosed
US-5210175-A Catalyst of platinum, palladium or nickel EASTMAN KODAK COMPANY (US) 1993-05-11 US disclosed
US-5206091-A Polyimides made from 2,2-bis/3,4-dicarboxyphenyl/propane or 2,2-bis/3,4-dicarboxyphenyl/hexafluoropropane and aromatic diamines AMOCO CORPORATION (US) 1993-04-27 US disclosed
WO-1993006151-A1 POLYIMIDE COPOLYMERS CONTAINING 3,3',4,4'-TETRACARBOXYBIPHENYL DIANHYDRIDE (BPDA) MOIETIES AMOCO CORPORATION (US) 1993-04-01 WO disclosed
US-5196549-A Dielectric films E. I. DU PONT DE NEMOURS AND COMPANY (US) 1993-03-23 US disclosed
WO-1993004033-A1 FLUORINE-CONTAINING DIAMINES, POLYAMIDES, AND POLYIMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-03-04 WO disclosed
US-5175367-A Fluorine-containing diamines, polyamides, and polyimides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1992-12-29 US disclosed
EP-0518196-A1 Polyethers based on 9,9-BIS-perfluoroalkyl-3,6-dihydroxy-xanthene or 9-aryl-9-perfluoroalkyl-3,6-dihydroxy-xanthene E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-12-16 EP disclosed
US-5153303-A Polyimides prepared from disubstituted aromatic tetracarboxylic acid dianhydrides CIBA-GEIGY CORPORATION (US) 1992-10-06 US disclosed
US-5137751-A Coating substrate with polyamic acid; imidizing AMOCO CORPORATION (US) 1992-08-11 US disclosed
US-5104946-A For heat resistant low dielectric coatings OCCIDENTAL CHEMICAL CORPORATION (US) 1992-04-14 US disclosed
US-5104946-A For heat resistant low dielectric coatings OCCIDENTAL CHEMICAL CORPORATION (US) 1992-04-14 US disclosed
EP-0448248-A2 Process for making thick multilayers AMOCO CORPORATION (US) 1991-09-25 EP disclosed
EP-0438751-A2 Solutions of polyimidesiloxanes in butyrolactone OCCIDENTAL CHEMICAL CORPORATION (US) 1991-07-31 EP disclosed
EP-0438751-A2 Solutions of polyimidesiloxanes in butyrolactone OCCIDENTAL CHEMICAL CORPORATION (US) 1991-07-31 EP disclosed
EP-0438382-A1 Disubstituted aromatic dianhydrides and polyimides prepared therefrom CIBA-GEIGY AG (CH) 1991-07-24 EP disclosed
US-5003037-A Films for protective coatings for dielectrics, electronics AMOCO CORPORATION (US) 1991-03-26 US disclosed
US-5003037-A Films for protective coatings for dielectrics, electronics AMOCO CORPORATION (US) 1991-03-26 US disclosed
US-5003037-A Films for protective coatings for dielectrics, electronics AMOCO CORPORATION (US) 1991-03-26 US disclosed
US-4992527-A Heat resistance, protective coatings, electronics AMOCO CORPORATION (US) 1991-02-12 US disclosed
US-4975521-A SOLUBLE, FILM FORMING AROMATIC POLYMER MADE FROM DIAMINE AND DIACID AMOCO CORPORATION (US) 1990-12-04 US disclosed
US-4975521-A SOLUBLE, FILM FORMING AROMATIC POLYMER MADE FROM DIAMINE AND DIACID AMOCO CORPORATION (US) 1990-12-04 US disclosed
US-4975521-A SOLUBLE, FILM FORMING AROMATIC POLYMER MADE FROM DIAMINE AND DIACID AMOCO CORPORATION (US) 1990-12-04 US disclosed
US-4973659-A HEAR RESISTANT FILMS, FIBERS, COMPOSITES AMOCO CORPORATION (US) 1990-11-27 US disclosed
US-4968780-A SOLUBLE IN N-METHYLPYRROLIDONE, HIGH GLASS TRANSITION TEMPERATURE, HEAT RESISTANT FILMS, FIBERS AND COMPOSITES AMOCO CORPORATION (US) 1990-11-06 US disclosed
US-4966955-A Aromatic copolyether amide which can be processed as a thermoplastic, process for its preparation, and its use for the production of molding HOECHST AKTIENGESELLSCHAFT (DE) 1990-10-30 US disclosed
US-4946934-A Useful for fiber making, coatings and films AMOCO CORPORATION (US) 1990-08-07 US disclosed
US-4946934-A Useful for fiber making, coatings and films AMOCO CORPORATION (US) 1990-08-07 US disclosed
US-4946934-A Useful for fiber making, coatings and films AMOCO CORPORATION (US) 1990-08-07 US disclosed
JP-H0260934-A POLYIMIDE AND COPOLYIMIDE WITH LOW DIELECTRIC CONSTANT AND LOW MOISTURE ABSORPTIVITY FOR INTERMEDIATE LAYER INSULATOR AND BASE FILM AMOCO CORP 1990-03-01 JP disclosed
EP-0344594-A1 Thermoplastic aromatic copolyetheramide, process for its preparation and its use to produce molded articles HOECHST AKTIENGESELLSCHAFT (DE) 1989-12-06 EP disclosed
EP-0344594-A1 Thermoplastic aromatic copolyetheramide, process for its preparation and its use to produce molded articles HOECHST AKTIENGESELLSCHAFT (DE) 1989-12-06 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180044288-A1 KINASE INHIBITORS SYK, LYN, BTK POLB 3321/4885GABRA1 3954/4885GABRB2 4459/4885
US-20210292436-A1 Methods of Inhibiting MASP-2 for the Treatment and/or Prevention of Coronavirus-induced Acute Respiratory Distress Syndrome MASP2, ACE2, MAS1 POLB 2415/4885GABRA1 3878/4885GABRB2 4083/4885
US-20160376232-A1 KINASE INHIBITORS LYN, SYK, LCK POLB 3696/4885GABRA1 1991/4885GABRB2 2824/4885
US-10100050-B2 Kinase inhibitors MAPK1, MAP3K1, MAP3K6 POLB 1467/4885GABRA1 4477/4885GABRB2 4343/4885
US-20210179612-A1 MASP-2 INHIBITORS AND METHODS OF USE MASP2, METAP2, SPINT2 POLB 2216/4885GABRA1 4177/4885GABRB2 2699/4885
US-20150166483-A1 KINASE INHIBITORS LCK, SYK, FYN POLB 3679/4885GABRA1 4374/4885GABRB2 4391/4885
US-20170183345-A1 KINASE INHIBITORS MAPK1, MAP3K1, MAP3K6 POLB 1467/4885GABRA1 4477/4885GABRB2 4343/4885
US-20250282736-A1 SMALL MOLECULE MODULATORS OF HUMAN PREGNANE X RECEPTOR NR1H4, NR1I2, NR1I3 POLB 3429/4885GABRA1 143/4885GABRB2 197/4885
US-10435361-B2 Kinase inhibitors SYK, LYN, BTK POLB 3321/4885GABRA1 3954/4885GABRB2 4459/4885
US-20260116867-A1 PROTEOLYSIS TARGETING CHIMERAS FOR HUMAN PREGNANE X RECEPTOR AND FOR DEGRADATION OF GSPT1 NR3C1, GPER1, NR1H4 POLB 3890/4885GABRA1 306/4885GABRB2 442/4885
US-20140296208-A1 KINASE INHIBITORS SYK, LYN, BTK POLB 3321/4885GABRA1 3954/4885GABRB2 4459/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.