Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP4 | P49662 | 1/20 | 0.48 |
| ▸ | CASP5 | P51878 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249152 | 0.94 | MEN1 (0.52) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL23369522 | 0.93 | ACHE (0.52) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL28257908 | 0.93 | ALDH1A1 (0.49) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL30543437 | 0.90 | ACHE (0.49) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL249415 | 0.90 | CYP2A13 (0.54) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL21240870 | 0.89 | ALDH1A1 (0.54) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| Hydrochloric Acid SCHEMBL17439173 | 0.88 | ALDH1A1 (0.53) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL16171455 | 0.88 | ALDH1A1 (0.53) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL16119494 | 0.85 | ALDH1A1 (0.54) | ACHEALDH1A1KDM4EPOLBMEN1 | |
| SCHEMBL28257896 | 0.85 | ALDH1A1 (0.47) | ACHEALDH1A1KDM4EPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230373955-A1 | SYNTHESIS OF OMECAMTIV MECARBIL | AMGEN INC. | 2023-11-23 | — | — | US | disclosed |
| US-11753394-B2 | Synthesis of omecamtiv mecarbil | AMGEN INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-11702380-B2 | Synthesis of omecamtiv mecarbil | AMGEN INC. (US) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702380-B2 | Synthesis of omecamtiv mecarbil | SI, MTHFD2, DPYD | ACHE 3865/4885ALDH1A1 1017/4885KDM4E 464/4885 |
| US-20230373955-A1 | SYNTHESIS OF OMECAMTIV MECARBIL | DPYD, SI, MTHFD2 | ACHE 3655/4885ALDH1A1 570/4885KDM4E 566/4885 |
| US-11753394-B2 | Synthesis of omecamtiv mecarbil | SI, DPYD, MTHFD2 | ACHE 3439/4885ALDH1A1 703/4885KDM4E 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.