Hydrochloric Acid

Hydrochloric Acid

SCHEMBL17439173

Cl.O=C(O)N1CCN(Cc2cccc([N+](=O)[O-])c2F)CC1

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 1/20 0.45
SIGMAR1 known ✓ Q99720 1/20 0.45
ALDH1A1 P00352 10/20 0.53
KDM4E B2RXH2 8/20 0.53
LMNA P02545 4/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
MEN1 O00255 3/20 0.48
KMT2A Q03164 3/20 0.48
HTT P42858 2/20 0.47
POLB P06746 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.44
PKM P14618 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21240870 0.99 ALDH1A1 (0.54) ALDH1A1KDM4ELMNASMN1; SMN2TDP1
SCHEMBL25937663 0.88 ACHE (0.55) ALDH1A1KDM4ELMNASMN1; SMN2TDP1
SCHEMBL16171455 0.88 ALDH1A1 (0.53) ALDH1A1KDM4ELMNASMN1; SMN2TDP1
Hydrochloric Acid SCHEMBL16165437 0.86 ALDH1A1 (0.53) ALDH1A1KDM4ELMNASMN1; SMN2TDP1
SCHEMBL16119494 0.84 ALDH1A1 (0.54) ALDH1A1KDM4ELMNASMN1; SMN2TDP1
SCHEMBL28257908 0.84 ALDH1A1 (0.49) ALDH1A1KDM4ELMNASMN1; SMN2TDP1
SCHEMBL249152 0.83 MEN1 (0.52) ALDH1A1KDM4ETDP1MEN1KMT2A
SCHEMBL23369522 0.82 ACHE (0.52) ALDH1A1KDM4ELMNATDP1MEN1
SCHEMBL26603989 0.82 ALDH1A1 (0.49) ALDH1A1KDM4ELMNASMN1; SMN2TDP1
SCHEMBL24113875 0.81 ALDH1A1 (0.51) ALDH1A1KDM4ELMNASMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583821-B2 Salt of omecamtiv mecarbil and process for preparing salt CYTOKINETICS, INC. (US) 2026-03-24 US disclosed
EP-2970123-B2 CRYSTALLINE DIHYDROCHLORIDE HYDRATE SALT OF OMECAMTIV MECARBIL AND PROCESS FOR ITS PREPARATION AMGEN INC (US) 2025-12-10 EP disclosed
US-20250243163-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT AMGEN INC. 2025-07-31 US disclosed
US-12221417-B2 Salt of omecamtiv mecarbil and process for preparing salt CYTOKINETICS, INC. (US) 2025-02-11 US disclosed
US-20240317687-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2024-09-26 US disclosed
US-11958809-B2 Salt of omecamtiv mecarbil and process for preparing salt CYTOKINETICS, INC. (US) 2024-04-16 US disclosed
US-20240101517-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT AMGEN INC. 2024-03-28 US disclosed
US-20230044617-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2023-02-09 US disclosed
US-11472773-B2 Salt of omecamtiv mecarbil and process for preparing salt CYTOKINETICS, INC. (US) 2022-10-18 US disclosed
US-20220153700-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2022-05-19 US disclosed
US-20200399221-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2020-12-24 US disclosed
US-20200331859-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2020-10-22 US disclosed
US-20200079736-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2020-03-12 US disclosed
EP-2970123-B1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT AMGEN INC (US) 2019-08-14 EP disclosed
US-20180312469-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT CYTOKINETICS, INC. 2018-11-01 US disclosed
US-9988354-B2 Salt of omecamtiv mecarbil and process for preparing salt AMGEN INC. (US) 2018-06-05 US disclosed
US-20160016906-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT AMGEN INC. (US) 2016-01-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230044617-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-20250243163-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-20220153700-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-20200331859-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-20240317687-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-11472773-B2 Salt of omecamtiv mecarbil and process for preparing salt SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-20180312469-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-20240101517-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-12583821-B2 Salt of omecamtiv mecarbil and process for preparing salt SLC28A2, SLC28A1, SLC5A11 ACHE 1380/4885SIGMAR1 1362/4885ALDH1A1 1521/4885
US-20200079736-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-11958809-B2 Salt of omecamtiv mecarbil and process for preparing salt SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-12221417-B2 Salt of omecamtiv mecarbil and process for preparing salt SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885
US-20160016906-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, AREG, CA12 ACHE 1336/4885SIGMAR1 3819/4885ALDH1A1 2291/4885
US-20200399221-A1 SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT SI, SLC5A6, SLC28A1 ACHE 3312/4885SIGMAR1 3199/4885ALDH1A1 1835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.