Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 8/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937688 | 0.85 | SIGMAR1 (0.38) | EGFRSIGMAR1RORC | |
| SCHEMBL25937403 | 0.84 | KCNQ2 (0.41) | TDP1POLBSIGMAR1RORC | |
| SCHEMBL25428080 | 0.83 | TP53 (0.41) | TP53TDP1MAPTEGFRERBB2 | |
| SCHEMBL25937883 | 0.80 | EGFR (0.40) | EGFRSIGMAR1AURKB | |
| SCHEMBL25937424 | 0.79 | NOTUM (0.53) | TP53MAPTRXFP1SIGMAR1 | |
| SCHEMBL25937779 | 0.79 | KDR (0.43) | TP53MAPTSIGMAR1 | |
| SCHEMBL25937545 | 0.78 | KCNQ2 (0.46) | SIGMAR1RORC | |
| SCHEMBL30557580 | 0.78 | KCNQ2 (0.46) | SIGMAR1RORC | |
| SCHEMBL25937565 | 0.78 | KCNQ2 (0.40) | TDP1POLBMAPTPKMSIGMAR1 | |
| SCHEMBL25937750 | 0.78 | SIGMAR1 (0.41) | EGFRSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |