Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25937886 | 0.85 | IKZF2 (0.45) | — | |
| SCHEMBL25937877 | 0.77 | CASP1 (0.31) | — | |
| SCHEMBL25993185 | 0.77 | METAP1 (0.34) | — | |
| SCHEMBL27311402 | 0.73 | MAPK14 (0.34) | PRMT5WDR77 | |
| SCHEMBL27122537 | 0.73 | SIGMAR1 (0.32) | — | |
| SCHEMBL25993687 | 0.72 | PRMT5 (0.32) | PRMT5WDR77 | |
| SCHEMBL25994276 | 0.71 | HRH3 (0.32) | PDK2 | |
| SCHEMBL27118055 | 0.69 | METAP1 (0.35) | — | |
| SCHEMBL27020519 | 0.68 | SIGMAR1 (0.32) | — | |
| SCHEMBL26022379 | 0.68 | METAP1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820574-B1 | 3-(5-AMINO-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF IKAROS FAMILY ZINC FINGER 2 (IKZF2)-DEPENDENT DISEASES | NOVARTIS AG (CH) | 2023-08-09 | — | — | EP | disclosed |