Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25943492 | 0.86 | TTR (0.48) | KDM4EALDH1A1TTRAPPPTPN1 | |
| SCHEMBL4190691 | 0.85 | EPHX2 (0.56) | KDM4EALDH1A1TTRAPPPTPN1 | |
| SCHEMBL4190688 | 0.85 | EPHX2 (0.56) | KDM4EALDH1A1TTRAPPPTPN1 | |
| SCHEMBL20551560 | 0.80 | P4HB (0.63) | KDM4EALDH1A1TTRAPPPTPN1 | |
| SCHEMBL20551559 | 0.80 | P4HB (0.63) | KDM4EALDH1A1TTRAPPPTPN1 | |
| SCHEMBL66903 | 0.79 | FDPS (0.53) | KDM4EALDH1A1TTRAPPEPHX2 | |
| SCHEMBL12215743 | 0.79 | TTR (0.54) | TTRAPPCA12CA1CA2 | |
| SCHEMBL29976409 | 0.76 | ALDH1A1 (0.38) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL12499900 | 0.76 | ALDH1A1 (0.38) | KDM4EALDH1A1CA1CA2CA9 | |
| SCHEMBL26750856 | 0.76 | TTR (0.51) | TTRAPPCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146892-A1 | BIPHENYL-SUBSTITUTED EPITHELIAL SODIUM CHANNEL BLOCKING COMPOUNDS | PARION SCIENCES, INC. (US) | 2023-08-03 | — | — | WO | disclosed |