Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 6/20 | 0.32 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14964461 | 0.85 | EIF4A3 (0.35) | METAP2EIF4A3 | |
| SCHEMBL18364549 | 0.80 | CTSL (0.37) | METAP2CTSLCTSSCTSK | |
| SCHEMBL27342165 | 0.79 | GABRA1 (0.35) | EIF4A3CTSSCTSK | |
| SCHEMBL8097072 | 0.76 | METAP2 (0.35) | METAP2F2RL1CTSLCTSSCTSK | |
| SCHEMBL24319896 | 0.75 | LMNA (0.38) | EIF4A3 | |
| SCHEMBL28940400 | 0.74 | — | — | |
| SCHEMBL22336230 | 0.73 | METAP2 (0.34) | METAP2CTSLCTSSCTSK | |
| SCHEMBL15417382 | 0.73 | EIF4A3 (0.35) | EIF4A3 | |
| SCHEMBL18364604 | 0.73 | CTSL (0.38) | CTSLCTSSCTSK | |
| SCHEMBL20622503 | 0.72 | EIF4A3 (0.40) | EIF4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3500556-B1 | PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-08-02 | — | — | EP | disclosed |