Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 2/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.31 |
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8089690 | 0.88 | TYR (0.44) | METAP2RIPK1TYRALOX5 | |
| SCHEMBL18364549 | 0.86 | CTSL (0.37) | METAP2CTSLCTSSCTSKTYR | |
| SCHEMBL18184381 | 0.84 | METAP2 (0.36) | METAP2CTSLCTSSCTSKRIPK1 | |
| SCHEMBL13692432 | 0.83 | TAAR1 (0.45) | — | |
| SCHEMBL8097082 | 0.82 | RIPK1 (0.38) | METAP2RIPK1P2RX7 | |
| SCHEMBL10061129 | 0.82 | RIPK1 (0.41) | F2RL1CTSLCTSSCTSKRIPK1 | |
| SCHEMBL17369452 | 0.81 | KCNH2 (0.39) | F2RL1P2RX7KCNH2 | |
| SCHEMBL22336230 | 0.79 | METAP2 (0.34) | METAP2CTSLCTSSCTSKTYR | |
| SCHEMBL18566713 | 0.77 | P2RX7 (0.33) | RIPK1P2RX7 | |
| SCHEMBL17369451 | 0.77 | P2RX7 (0.36) | CTSLCTSSCTSKRIPK1PRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2966076-A1 | NOVEL TYROSINE KINASE INHIBITORS | ChemBridge Corporation (US) | 2016-01-13 | — | — | EP | disclosed |
| EP-2262807-B1 | NOVEL TYROSINE KINASE INHIBITORS | CHEMBRIDGE CORP (US) | 2015-08-12 | — | — | EP | disclosed |
| EP-1053990-A2 | A method of producing an aromatic ketone and an aromatic ketone composition containing it | TORAY INDUSTRIES, INC. (JP) | 2000-11-22 | — | — | EP | disclosed |