Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588801 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2CYP1A2LMNATP53HPGD | |
| SCHEMBL2594547 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP1A2LMNAARHTR1A | |
| SCHEMBL10657341 | 0.72 | TRPA1 (0.47) | SMN1; SMN2MEN1LMNATP53HPGD | |
| SCHEMBL3691354 | 0.70 | ALDH1A1 (0.48) | SMN1; SMN2CYP1A2MEN1LMNATP53 | |
| SCHEMBL5539379 | 0.70 | HTR1A (0.54) | MEN1LMNATP53MAPK1KMT2A | |
| SCHEMBL1332713 | 0.69 | PARP1 (0.47) | MEN1LMNAHPGDMAPK1KMT2A | |
| SCHEMBL30819181 | 0.69 | PARP1 (0.47) | MEN1LMNAHPGDMAPK1KMT2A | |
| SCHEMBL27469327 | 0.69 | SLC22A12 (0.39) | SMN1; SMN2CYP1A2LMNAHTR1AADRA1D | |
| SCHEMBL9360680 | 0.68 | CA12 (0.44) | SMN1; SMN2CYP1A2MEN1LMNATP53 | |
| SCHEMBL2595670 | 0.68 | RIPK2 (0.42) | SMN1; SMN2CYP1A2MEN1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566477-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | Glaxo Group Limited (GB) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140442-A1 | AMINO-QUINOLINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-11-10 | — | — | WO | disclosed |