Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
| ▸ | NOS1 | P29475 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAD52 | P43351 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11061990 | 0.86 | TRPA1 (0.47) | TRPA1NOS3NOS1NOS2ACVR1 | |
| SCHEMBL27469327 | 0.81 | SLC22A12 (0.39) | NOS3NOS1NOS2KITCDK8 | |
| SCHEMBL19506247 | 0.80 | SMN1; SMN2 (0.49) | NOS3NOS1NOS2KITCDK8 | |
| SCHEMBL26325454 | 0.80 | NOS3 (0.44) | NOS3NOS1NOS2KITCDK8 | |
| SCHEMBL12044447 | 0.79 | NR4A2 (0.56) | NOS3NOS1NOS2KITCDK8 | |
| SCHEMBL14690592 | 0.79 | NOS3 (0.43) | NOS3NOS1NOS2KITCDK8 | |
| SCHEMBL26349519 | 0.79 | NOS3 (0.43) | TRPA1NOS3NOS1NOS2KIT | |
| SCHEMBL24368246 | 0.78 | KDM4E (0.51) | ALDH1A1KMT2AMEN1SLC22A12MAPT | |
| SCHEMBL3862227 | 0.78 | IDH1 (0.51) | CDK8SLC22A12KDM4E | |
| SCHEMBL27907349 | 0.78 | SLC22A12 (0.39) | KITCDK8ACVR1CLK4MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11820766-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-21 | — | — | US | disclosed |
| US-20200102311-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-02 | — | — | US | disclosed |
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC (US) | 2015-01-29 | — | — | US | disclosed |
| CN-1835944-A | Quinolyl amide derivatives as CCR-5 antagonists | SCHERING AG (DE) | 2006-09-20 | — | — | CN | disclosed |
| EP-0168309-B1 | ISOXAZOLOQUINOLINONE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1988-03-09 | — | — | EP | disclosed |
| EP-0168309-A1 | Isoxazoloquinolinone derivatives, process and intermediates for their preparation, use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1986-01-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | TRPM8, TRPM5, TRPM7 | TRPA1 9/4885NOS3 2426/4885NOS1 2789/4885 |
| US-20200102311-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | TRPA1 1859/4885NOS3 3565/4885NOS1 3670/4885 |
| US-11820766-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, PNLIP | TRPA1 1604/4885NOS3 3384/4885NOS1 3648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.