Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 14/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2595192 | 0.87 | ICMT (0.74) | ICMTPLA2G2AALDH1A1SMN1; SMN2 | |
| SCHEMBL8289938 | 0.86 | PLA2G2A (0.74) | ICMTPLA2G2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4359581 | 0.84 | HTR6 (0.69) | HTR6ALDH1A1CYP1A2CYP3A4GAA | |
| SCHEMBL8183003 | 0.83 | ALDH1A1 (0.56) | ICMTHTR6PLA2G2AALDH1A1CYP1A2 | |
| SCHEMBL3855663 | 0.82 | HTR6 (0.57) | ICMTHTR6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3855666 | 0.82 | HTR6 (0.57) | ICMTHTR6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL8178374 | 0.81 | HTR6 (0.62) | ICMTHTR6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL3850017 | 0.81 | HTR6 (0.55) | ICMTHTR6ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4435107 | 0.81 | PLA2G2A (0.57) | ICMTHTR6PLA2G2AALDH1A1MAPT | |
| SCHEMBL4927838 | 0.80 | HTR6 (0.54) | ICMTHTR6ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |