Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 14/20 | 0.74 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594641 | 0.87 | ICMT (0.65) | ICMTPLA2G2AALDH1A1SMN1; SMN2 | |
| SCHEMBL4354844 | 0.86 | ICMT (0.54) | ICMTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL3859905 | 0.84 | ADAM17 (0.55) | ICMTALDH1A1LMNA | |
| SCHEMBL3859902 | 0.84 | ADAM17 (0.55) | ICMTALDH1A1LMNA | |
| SCHEMBL9231831 | 0.83 | ICMT (1.00) | ICMT | |
| SCHEMBL8289938 | 0.83 | PLA2G2A (0.74) | ICMTPLA2G2AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL16026993 | 0.82 | HTR6 (0.55) | ICMTALDH1A1SMN1; SMN2 | |
| SCHEMBL8176536 | 0.81 | ICMT (0.63) | ICMTALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8806145 | 0.81 | YES1 (0.55) | ICMTALDH1A1LMNA | |
| SCHEMBL3849405 | 0.80 | ADAM17 (0.54) | ICMTPLA2G2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |