SCHEMBL2594655

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL2592542	0.90	CDK8 (0.50)	PIK3CAPIK3CGKDRPIK3CDPIK3CB
	SCHEMBL2592470	0.82	MAP4K1 (0.45)	PIK3CAPIK3CGKDRPIK3CDPIK3CB
	SCHEMBL2594319	0.78	EZH2 (0.59)	—
	SCHEMBL2588507	0.76	MTOR (0.38)	PIK3CAMTORROCK2ROCK1LRRK2
	SCHEMBL2595663	0.75	RIPK1 (0.51)	PIK3CAPIK3CGKDRPIK3CDPIK3CB
	SCHEMBL2594202	0.75	KDM4E (0.41)	PIK3CAPIK3CGKDRPIK3CDPIK3CB
	SCHEMBL2592103	0.74	CDK8 (0.52)	PIK3CAPIK3CGKDRPIK3CDPIK3CB
	SCHEMBL2592084	0.69	KDM4E (0.41)	—
	SCHEMBL18766941	0.69	ITK (0.61)	PIK3CAPIK3CGKDRPIK3CDPIK3CB
	SCHEMBL2592086	0.68	ROCK2 (0.40)	PIK3CAMTORROCK2ROCK1LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.