Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | CFD | P00746 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PER2 | O15055 | 1/20 | 0.35 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.35 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711206 | 0.96 | HCRTR2 (0.55) | HCRTR2HCRTR1OPRM1TMEM97CFD | |
| SCHEMBL7707039 | 0.94 | HCRTR2 (0.47) | HCRTR2HCRTR1OPRM1TMEM97CFD | |
| SCHEMBL7702319 | 0.81 | HCRTR2 (0.47) | HCRTR2HCRTR1PTGDR2 | |
| SCHEMBL2592050 | 0.81 | THRB (0.46) | HCRTR2HCRTR1 | |
| SCHEMBL7702650 | 0.79 | HCRTR2 (0.78) | HCRTR2HCRTR1 | |
| SCHEMBL7709100 | 0.77 | SMN1; SMN2 (0.51) | HCRTR2HCRTR1GAA | |
| SCHEMBL2588992 | 0.77 | HCRTR2 (0.44) | HCRTR2HCRTR1 | |
| SCHEMBL7713631 | 0.76 | HCRTR2 (0.61) | HCRTR2HCRTR1 | |
| SCHEMBL7713640 | 0.75 | HCRTR2 (0.54) | HCRTR2HCRTR1PTGDR2 | |
| SCHEMBL2594744 | 0.75 | HCRTR1 (0.48) | HCRTR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138265-A2 | INDOLE AND INDAZOLE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |