SCHEMBL25947900

SCHEMBL25947900

CCOC(=O)c1c(CN)n(C)c2cc(C3CC3)c(-c3cccc4ccccc34)cc12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PKM P14618 1/20 0.44
MAPT P10636 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
TSHR P16473 1/20 0.41
CACNA1C Q13936 1/20 0.41
ALOX5 P09917 5/20 0.40
KMT2A Q03164 4/20 0.40
MEN1 O00255 2/20 0.40
KDM4E B2RXH2 4/20 0.40
GABRP O00591 1/20 0.38
GABRD O14764 1/20 0.38
GABRA1 P14867 1/20 0.38
GABRB1 P18505 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA5 P31644 1/20 0.38
GABRA3 P34903 1/20 0.38
GABRA2 P47869 1/20 0.38
GABRB2 P47870 1/20 0.38
GABRA4 P48169 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25947741 0.96 PKM (0.43) PKMMAPTNPSR1TSHRCACNA1C
SCHEMBL25947211 0.96 PKM (0.42) PKMMAPTNPSR1TSHRCACNA1C
SCHEMBL25947315 0.93 TSHR (0.41) PKMMAPTNPSR1TSHRCACNA1C
SCHEMBL25949845 0.89 PKM (0.45) PKMMAPTNPSR1TSHRCACNA1C
SCHEMBL25939889 0.88 PKM (0.41) PKMMAPTNPSR1TSHRCACNA1C
SCHEMBL25949793 0.86 PKM (0.44) PKMMAPTNPSR1TSHRCACNA1C
SCHEMBL25947856 0.85 TSHR (0.49) PKMMAPTNPSR1TSHRALOX5
SCHEMBL25939765 0.85 KDM4E (0.39) PKMMAPTNPSR1TSHRCACNA1C
SCHEMBL25947457 0.84 TSHR (0.48) PKMMAPTNPSR1TSHRALOX5
SCHEMBL25946425 0.83 ALOX5 (0.47) MAPTNPSR1TSHRALOX5KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4209492-A1 COMPOUND FOR TREATING THROMBOTIC DISEASES Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) 2023-07-12 EP disclosed