SCHEMBL25949649

SCHEMBL25949649

CCc1c(C)cc(OS(=O)(=O)C(F)(F)F)c(C)c1C

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 7/20 0.34
DRD3 P35462 6/20 0.34
DRD4 P21917 4/20 0.34
DRD1 P21728 2/20 0.34
DRD5 P21918 2/20 0.34
HTR1D P28221 2/20 0.32
HTR5A P47898 1/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrogen Sulfide SCHEMBL15796096 0.80 ESR2 (0.33) DRD2DRD3DRD4DRD1DRD5
SCHEMBL14240535 0.77 DRD2 (0.38) DRD2DRD3DRD4DRD1DRD5
SCHEMBL25949682 0.76 EPAS1 (0.33) DRD2DRD3DRD4DRD1DRD5
SCHEMBL20739385 0.76 CETP (0.34) DRD2DRD3DRD4DRD1DRD5
SCHEMBL6938167 0.74 DRD2 (0.34) DRD2DRD3DRD4DRD1DRD5
SCHEMBL6740755 0.73 ALDH1A1 (0.41) MEN1ALDH1A1MAPTKMT2A
SCHEMBL7030271 0.73 DRD2 (0.32) DRD2DRD3DRD4DRD1DRD5
SCHEMBL30487004 0.72 ADORA1 (0.33) DRD2DRD3DRD4DRD1DRD5
SCHEMBL11701524 0.72 ADORA1 (0.31)
SCHEMBL17864633 0.71 MEN1 (0.41) MEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242471-A1 THYROMIMETICS AUTOBAHN THERAPEUTICS, INC. 2023-08-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242471-A1 THYROMIMETICS TPO, THOP1, THRB DRD2 3184/4885DRD3 3275/4885DRD4 3522/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.