SCHEMBL2595412

SCHEMBL2595412

O=[N+]([O-])c1ccc(CCBr)c(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.56
KMT2A Q03164 2/20 0.46
ALDH1A1 P00352 4/20 0.46
VCAM1 P19320 1/20 0.44
PDE7A Q13946 5/20 0.43
GSK3B P49841 1/20 0.42
TDP1 Q9NUW8 2/20 0.42
CYP1A2 P05177 1/20 0.41
LMNA P02545 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
PDE4B Q07343 1/20 0.41
PDE4D Q08499 1/20 0.41
PDE7B Q9NP56 1/20 0.41
CYP3A4 P08684 1/20 0.41
SIRT2 Q8IXJ6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30001251 1.00 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL27796780 0.86 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1GSK3B
SCHEMBL508763 0.86 HSD17B10 (0.60) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL29672035 0.86 HSD17B10 (0.60) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL23883005 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL11369484 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL28239875 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL30002362 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL30001924 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL2589891 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250333407-A1 Compounds and Their Use for Treatment of Hemoglobinopathies BRISTOL-MYERS SQUIBB COMPANY (US) 2025-10-30 US disclosed
US-20250144230-A1 LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES ORUM THERAPEUTICS, INC. (KR) 2025-05-08 US disclosed
US-20240252671-A1 NEODEGRADER-ANTI-CD33 ANTIBODY CONJUGATES ORUM THERAPEUTICS INC (KR) 2024-08-01 US disclosed
EP-4398942-A1 LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES Orum Therapeutics Inc. (KR) 2024-07-17 EP disclosed
CN-118201641-A Novel degradant-anti-CD 33 antibody conjugates 奥隆制药 2024-06-14 CN disclosed
CN-118201642-A Linker for antibody drug conjugates 奥隆制药 2024-06-14 CN disclosed
US-20230338564-A1 NEODEGRADER CONJUGATES ORUM THERAPEUTICS, INC. (FR) 2023-10-26 US disclosed
CN-115867322-A Novel degradant conjugates 奥隆制药 2023-03-28 CN disclosed
WO-2023037268-A1 LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES ORUM THERAPEUTICS, INC. (KR) 2023-03-16 WO disclosed
EP-4126067-A1 NEODEGRADER CONJUGATES Orum Therapeutics Inc. (KR) 2023-02-08 EP disclosed
CN-103044432-A Bicyclic heteroaryl compounds ARIAD PHARMA INC 2013-04-17 CN disclosed
EP-2569290-A2 PHARMACEUTICAL COMPOUNDS Sentinel Oncology Limited (GB) 2013-03-20 EP disclosed
US-20130065900-A1 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LIMITED (GB) 2013-03-14 US disclosed
WO-2011141716-A2 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LIMITED (GB) 2011-11-17 WO disclosed
CN-101490053-A Monocyclic Heteroaryl Compounds ARIAD PHARMA INC (US) 2009-07-22 CN disclosed
CN-1165532-C Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors ���Ͽع����޹�˾ 2004-09-08 CN disclosed
EP-1043308-B1 PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME KISSEI PHARMACEUTICAL (JP) 2003-09-24 EP disclosed
US-6353025-B1 COMPOUNDS AS DRUGS KISSEI PHARMACEUTICAL CO., LTD. (JP) 2002-03-05 US disclosed
CN-1320121-A Substituted 3-cyanoquinolines as protein tyrosine kinase inhibitors AMERICAN CYANAMID CO (US) 2001-10-31 CN disclosed
EP-1043308-A1 PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME Kissei Pharmaceutical Co., Ltd. (JP) 2000-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240252671-A1 NEODEGRADER-ANTI-CD33 ANTIBODY CONJUGATES NEU3, FCGR3B, ENTPD3 HSD17B10 2571/4885KMT2A 2655/4885ALDH1A1 685/4885
US-20130065900-A1 PHARMACEUTICAL COMPOUNDS CSNK1A1, FRK, CSNK1E HSD17B10 2176/4885KMT2A 1629/4885ALDH1A1 3289/4885
US-20230338564-A1 NEODEGRADER CONJUGATES CD44, FOLR1, CD47 HSD17B10 1567/4885KMT2A 2917/4885ALDH1A1 275/4885
US-20250144230-A1 LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES CD2BP2, CD47, EPCAM HSD17B10 3930/4885KMT2A 1804/4885ALDH1A1 2708/4885
US-20250333407-A1 Compounds and Their Use for Treatment of Hemoglobinopathies HBG1, HBG2, HBB HSD17B10 658/4885KMT2A 1728/4885ALDH1A1 424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.