SCHEMBL2589891

SCHEMBL2589891

O=[N+]([O-])c1ccc(CCO)c(Cl)c1

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.56
TSHR P16473 1/20 0.53
KMT2A Q03164 2/20 0.50
ALDH1A1 P00352 4/20 0.46
CYP1A2 P05177 1/20 0.45
VCAM1 P19320 1/20 0.44
PDE7A Q13946 1/20 0.43
LMNA P02545 2/20 0.43
KDM4E B2RXH2 1/20 0.43
GPR35 Q9HC97 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
TDP1 Q9NUW8 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30001924 1.00 HSD17B10 (0.56) HSD17B10TSHRKMT2AALDH1A1CYP1A2
SCHEMBL4014324 0.90 HSD17B10 (0.53) HSD17B10TSHRKMT2AALDH1A1CYP1A2
SCHEMBL4513003 0.86 HSD17B10 (0.56) HSD17B10TSHRKMT2AALDH1A1CYP1A2
SCHEMBL844111 0.86 HSD17B10 (0.60) HSD17B10KMT2AALDH1A1CYP1A2VCAM1
SCHEMBL6295397 0.84 TSHR (0.58) HSD17B10TSHRKMT2AALDH1A1CYP1A2
SCHEMBL23883005 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1CYP1A2VCAM1
SCHEMBL2595412 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1CYP1A2VCAM1
SCHEMBL11369484 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1VCAM1PDE7A
SCHEMBL30002362 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1CYP1A2VCAM1
SCHEMBL28239875 0.83 HSD17B10 (0.56) HSD17B10KMT2AALDH1A1CYP1A2VCAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026077418-A9 ISOINDOLINE COMPOUND CONTAINING PHENYLETHOXYALKYLENEAMINE STRUCTURE, CONJUGATE THEREOF, AND USE THEREOF 上海海雁医药科技有限公司 2026-05-15 WO disclosed
US-20250361234-A1 COMPOUNDS, COMPOSITIONS, AND METHODS NICO THERAPEUTICS INC (US) 2025-11-27 US disclosed
US-20250333407-A1 Compounds and Their Use for Treatment of Hemoglobinopathies BRISTOL-MYERS SQUIBB COMPANY (US) 2025-10-30 US disclosed
US-20250144230-A1 LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES ORUM THERAPEUTICS, INC. (KR) 2025-05-08 US disclosed
EP-4536637-A2 COMPOUNDS, COMPOSITIONS, AND METHODS Nico Therapeutics, Inc. (US) 2025-04-16 EP disclosed
US-20250090681-A1 NEODEGRADER CONJUGATES ORUM THERAPEUTICS INC (KR) 2025-03-20 US disclosed
US-20240252671-A1 NEODEGRADER-ANTI-CD33 ANTIBODY CONJUGATES ORUM THERAPEUTICS INC (KR) 2024-08-01 US disclosed
EP-4398942-A1 LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES Orum Therapeutics Inc. (KR) 2024-07-17 EP disclosed
CN-118201642-A Linker for antibody drug conjugates 奥隆制药 2024-06-14 CN disclosed
CN-118201641-A Novel degradant-anti-CD 33 antibody conjugates 奥隆制药 2024-06-14 CN disclosed
US-20130065900-A1 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LIMITED (GB) 2013-03-14 US disclosed
WO-2011141716-A2 PHARMACEUTICAL COMPOUNDS SENTINEL ONCOLOGY LIMITED (GB) 2011-11-17 WO disclosed
US-6790865-B2 2-HYDROXY-2-(4-HYDROXYPHENYL)-1-METHYLETHYL)AMINO)ETHYL)PHENOXY OR IMINO)-2-METHYLPROPIONIC ACID DERIVATIVE EXCELLENT BETA 3-ADRENOCEPTOR STIMULANTS KISSEI PHARMACEUTICAL CO., LTD. (JP) 2004-09-14 US disclosed
EP-1072583-B1 2-METHYLPROPIONIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME KISSEI PHARMACEUTICAL (JP) 2004-09-01 EP disclosed
US-6696489-B1 PHENOLIC AND PHENYLAMINO SUBSTITUENTS; BETA 3-ADRENOCEPTOR AGONISTS; OBESITY, HYPERGLYCEMIA, INTESTINAL HYPERMOTILITY, POLLAKIURIA, URINARY INCONTINENCE, DEPRESSION KISSEI PHARMACEUTICAL CO., LTD. (JP) 2004-02-24 US disclosed
EP-1043308-B1 PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME KISSEI PHARMACEUTICAL (JP) 2003-09-24 EP disclosed
US-20030166719-A1 2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)phenoxy or imino)-2-methylpropionic acid derivative excellent beta 3-adrenoceptor stimulants KISSEI PHARMACEUTICAL CO., LTD. 2003-09-04 US disclosed
US-6353025-B1 COMPOUNDS AS DRUGS KISSEI PHARMACEUTICAL CO., LTD. (JP) 2002-03-05 US disclosed
EP-1072583-A1 2-METHYLPROPIONIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME Kissei Pharmaceutical Co., Ltd. (JP) 2001-01-31 EP disclosed
EP-1043308-A1 PHENYLAMINOALKYLCARBOXYLIC ACID DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME Kissei Pharmaceutical Co., Ltd. (JP) 2000-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250090681-A1 NEODEGRADER CONJUGATES CD44, FOLR1, CD47 HSD17B10 1567/4885TSHR 1338/4885KMT2A 2917/4885
US-20240252671-A1 NEODEGRADER-ANTI-CD33 ANTIBODY CONJUGATES NEU3, FCGR3B, ENTPD3 HSD17B10 2571/4885TSHR 713/4885KMT2A 2655/4885
US-20130065900-A1 PHARMACEUTICAL COMPOUNDS CSNK1A1, FRK, CSNK1E HSD17B10 2176/4885TSHR 1074/4885KMT2A 1629/4885
US-20250361234-A1 COMPOUNDS, COMPOSITIONS, AND METHODS SARM1, SARS1, TIAM1 HSD17B10 3635/4885TSHR 4280/4885KMT2A 3835/4885
US-20030166719-A1 2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl)amino)ethyl)phenoxy or imino)-2-methylpropionic acid derivative excellent beta 3-adrenoceptor stimulants ADRB1, ADRB2, ADRA2A HSD17B10 542/4885TSHR 1083/4885KMT2A 1886/4885
US-20250144230-A1 LINKERS FOR USE IN ANTIBODY DRUG CONJUGATES CD2BP2, CD47, EPCAM HSD17B10 3930/4885TSHR 2670/4885KMT2A 1804/4885
US-20250333407-A1 Compounds and Their Use for Treatment of Hemoglobinopathies HBG1, HBG2, HBB HSD17B10 658/4885TSHR 2158/4885KMT2A 1728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.