Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.68 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11523529 | 0.84 | HSD17B1 (0.58) | S1PR1ALOX15S1PR5HSD17B1ADORA1 | |
| SCHEMBL11520987 | 0.84 | HSD17B1 (0.62) | S1PR1ALOX15S1PR5HSD17B1ADORA1 | |
| SCHEMBL29389224 | 0.82 | S1PR1 (1.00) | S1PR1ALOX15S1PR5ALDH1A1SMN1; SMN2 | |
| SCHEMBL436150 | 0.82 | S1PR1 (1.00) | S1PR1ALOX15S1PR5ALDH1A1SMN1; SMN2 | |
| SCHEMBL11522626 | 0.81 | HSD17B1 (0.54) | S1PR1ALOX15S1PR5HSD17B1ADORA1 | |
| SCHEMBL28667956 | 0.77 | ADORA2A (0.54) | ADORA1ADORA2ASCN2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17335798 | 0.76 | S1PR1 (0.55) | S1PR1ALOX15S1PR5PLK1ADORA1 | |
| SCHEMBL307920 | 0.74 | KIF11 (0.62) | ADORA1ADORA2ASCN2AALDH1A1MAOB | |
| SCHEMBL29420699 | 0.74 | KIF11 (0.62) | ADORA1ADORA2ASCN2AALDH1A1MAOB | |
| SCHEMBL11520757 | 0.74 | HSD17B1 (0.58) | S1PR1ALOX15S1PR5HSD17B1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822595-A1 | USE OF SPHINGOSINE-1 -PHOSPHATE RECEPTORS MODULATORS FOR IMPROVING VACCINE IMMUNIZATION | Istituto Superiore di Sanità (IT) | 2015-01-14 | — | — | EP | disclosed |
| WO-2013132526-A1 | USE OF SPHINGOSINE-1 -PHOSPHATE RECEPTORS MODULATORS FOR IMPROVING VACCINE IMMUNIZATION | ISTITUTO SUPERIORE DI SANITA' (IT) | 2013-09-12 | — | — | WO | disclosed |
| EP-2566954-A1 | IMMUNOTHERAPY USING REDIRECTED ALLOGENEIC CELLS | Yeda Research and Development Co. Ltd. (IL) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140170-A1 | IMMUNOTHERAPY USING REDIRECTED ALLOGENEIC CELLS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2011-11-10 | — | — | WO | disclosed |