Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A1 | P04798 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | F2RL3 | Q96RI0 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013285 | 0.82 | PDE4A (0.52) | CYP1A1CYP1A2CYP1B1CYP19A1CYP11B1 | |
| SCHEMBL4454661 | 0.72 | CYP11B2 (0.66) | CYP1A2CYP19A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL7398618 | 0.72 | NPC1 (0.56) | CYP19A1CYP11B1CYP11B2KDM4ENPC1 | |
| SCHEMBL4702517 | 0.71 | NPC1 (0.80) | CYP19A1CYP11B1CYP11B2KDM4ENPC1 | |
| Bromide SCHEMBL7398620 | 0.70 | NPC1 (0.78) | CYP19A1CYP11B1CYP11B2KDM4ENPC1 | |
| SCHEMBL25218648 | 0.70 | KDM4E (0.42) | CYP1A1CYP1A2CYP1B1CYP19A1CYP11B1 | |
| SCHEMBL5457223 | 0.70 | MAPK1 (0.51) | CYP19A1CYP11B1CYP11B2KDM4ENPC1 | |
| SCHEMBL30461684 | 0.70 | KDM4E (0.42) | CYP1A1CYP1A2CYP1B1CYP19A1CYP11B1 | |
| SCHEMBL16345751 | 0.70 | F2RL3 (0.46) | KDM4ENPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7015113 | 0.69 | CYP1A2 (0.49) | CYP1A1CYP1A2CYP1B1CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8835659-B2 | Polysubstituted benzofurans and medicinal applications thereof | IKERCHEM, S.L. (ES) | 2014-09-16 | — | — | US | disclosed |
| US-20130217730-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | IKERCHEM, S.L. (ES) | 2013-08-22 | — | — | US | disclosed |
| EP-2569292-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | Ikerchem, S.L. (ES) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141458-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | IKERCHEM, S.L. (ES) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217730-A1 | POLYSUBSTITUTED BENZOFURANS AND MEDICINAL APPLICATIONS THEREOF | AGER, TFEB, FPGS | CYP1A1 349/4885CYP1A2 345/4885CYP1B1 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.