Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7013285 | 0.80 | PDE4A (0.52) | CYP1A2CYP1A1CYP1B1PDE4APDE4B | |
| SCHEMBL7015189 | 0.76 | PDE4A (0.64) | CYP1A2CYP1A1CYP1B1PDE4APDE4B | |
| SCHEMBL21735530 | 0.73 | CYP19A1 (0.62) | CYP1A2KDM4EKMT2AMEN1PPARG | |
| SCHEMBL30461597 | 0.71 | CYP2A6 (0.47) | CYP1A2CYP1A1CYP1B1KDM4EKMT2A | |
| SCHEMBL15867533 | 0.71 | CYP19A1 (0.51) | CYP1A2CYP1A1CYP1B1KDM4EKMT2A | |
| SCHEMBL16650194 | 0.71 | KDM4E (0.40) | CYP1A2CYP1A1CYP1B1PDE4AKDM4E | |
| SCHEMBL2596459 | 0.69 | CYP1A1 (0.58) | CYP1A2CYP1A1CYP1B1PDE4AKDM4E | |
| SCHEMBL16651640 | 0.69 | TRPA1 (0.40) | CYP1A2PDE4AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7019368 | 0.69 | CCR1 (0.37) | CYP1A2KDM4ESMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL16651306 | 0.69 | ALDH1A1 (0.35) | CYP1A2KDM4EKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1086106-B1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LTD (GB) | 2003-08-20 | — | — | EP | disclosed |
| EP-1086106-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | Darwin Discovery Limited (GB) | 2001-03-28 | — | — | EP | disclosed |
| US-6169090-B1 | FOR INHIBITION OF PHOSPHODIESTERASE IV | DARWIN DISCOVERY, LTD. (GB) | 2001-01-02 | — | — | US | disclosed |
| WO-1999064423-A1 | FUROPYRIDINE DERIVATIVES AND THEIR THERAPEUTICAL USE | DARWIN DISCOVERY LIMITED (GB) | 1999-12-16 | — | — | WO | disclosed |