SCHEMBL25969440

SCHEMBL25969440

C=C1CCCN1CCc1c(I)[nH]c2ccc(OC)cc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
CYP1A2 P05177 3/20 0.50
CYP2C9 P11712 3/20 0.50
MTNR1A P48039 3/20 0.50
MTNR1B P49286 3/20 0.50
CYP2D6 P10635 2/20 0.50
CYP3A4 P08684 2/20 0.50
CYP2C19 P33261 2/20 0.50
NQO2 P16083 1/20 0.50
ALDH1A1 P00352 7/20 0.47
KDM4E B2RXH2 4/20 0.43
MAPT P10636 3/20 0.43
HTR6 P50406 4/20 0.42
GAA P10253 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
KDR P35968 1/20 0.41
HTR1D P28221 2/20 0.41
HSD17B10 Q99714 3/20 0.41
USP2 O75604 1/20 0.41
ALOX15 P16050 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25969434 0.88 HTR1D (0.56) TSHRMTNR1AMTNR1BALDH1A1KDM4E
SCHEMBL25969475 0.77 TSHR (0.56) TSHRCYP1A2CYP2C9MTNR1AMTNR1B
SCHEMBL25969437 0.74 MTNR1A (0.64) TSHRCYP1A2CYP2C9MTNR1AMTNR1B
SCHEMBL8946961 0.73 HTR6 (0.72) TSHRCYP1A2CYP2C9MTNR1AMTNR1B
Iodomelatonin SCHEMBL163451 0.67 MTNR1A (1.00) TSHRCYP1A2CYP2C9MTNR1AMTNR1B
SCHEMBL11520036 0.65 HTR1D (0.62) TSHRMTNR1AMTNR1BALDH1A1KDM4E
SCHEMBL8946919 0.65 MTNR1A (0.78) TSHRCYP1A2CYP2C9MTNR1AMTNR1B
SCHEMBL4756887 0.65 ALDH1A1 (1.00) TSHRCYP1A2CYP2C9MTNR1AMTNR1B
SCHEMBL29409541 0.65 ALDH1A1 (0.80) TSHRCYP1A2CYP2C9MTNR1AMTNR1B
SCHEMBL25969463 0.64 HTR1D (0.64) TSHRMTNR1AMTNR1BALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023150547-A2 PSYCHEDELIC COMPOUNDS AND THEIR THERAPEUTIC USES CAAMTECH, INC. (US) 2023-08-10 WO disclosed