Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.36 |
| ▸ | CDK9 | P50750 | 5/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.36 |
| ▸ | CDK1 | P06493 | 4/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.36 |
| ▸ | CDK7 | P50613 | 3/20 | 0.36 |
| ▸ | CCNH | P51946 | 3/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597608 | 0.80 | CCNT1 (0.47) | RPS6KA3APPTBK1CCNT1CDK2 | |
| SCHEMBL31054180 | 0.77 | CCNT1 (0.52) | TBK1CCNT1CDK2CDK9CCNA2 | |
| SCHEMBL2597569 | 0.77 | CCNT1 (0.52) | TBK1CCNT1CDK2CDK9CCNA2 | |
| SCHEMBL2597630 | 0.72 | JAK2 (0.51) | TBK1CCNT1CDK2CDK9CDK1 | |
| SCHEMBL2598615 | 0.72 | JAK2 (0.45) | TBK1CCNT1CDK2CDK9CCNA2 | |
| SCHEMBL2597585 | 0.72 | HDAC3 (0.48) | TBK1CCNT1CDK2CDK9CCNA2 | |
| SCHEMBL2597602 | 0.72 | KDR (0.44) | APPCDK1SYKKDR | |
| SCHEMBL2597767 | 0.69 | CCNT1 (0.42) | TBK1CCNT1CDK2CDK9CCNA2 | |
| SCHEMBL2597598 | 0.69 | HDAC3 (0.53) | TBK1CCNT1CDK2CDK9CCNA2 | |
| SCHEMBL2597549 | 0.69 | CCNT1 (0.43) | TBK1CCNT1CDK2CDK9JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571856-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | claimed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | claimed |
| EP-2571856-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |