Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2597608 | 0.82 | CCNT1 (0.47) | APPCDK1 | |
| SCHEMBL31054180 | 0.80 | CCNT1 (0.52) | CDK1SYK | |
| SCHEMBL2597569 | 0.80 | CCNT1 (0.52) | CDK1SYK | |
| SCHEMBL2597599 | 0.75 | MAOB (0.47) | KDRCDK1SYKGRM4ABCG2 | |
| SCHEMBL2597600 | 0.74 | SYK (0.49) | KDREGFRERBB2SYKGRM4 | |
| SCHEMBL2598615 | 0.73 | JAK2 (0.45) | CDK1SYK | |
| SCHEMBL2597643 | 0.72 | GRM5 (0.44) | KDRAPPCDK1SYK | |
| SCHEMBL2597585 | 0.68 | HDAC3 (0.48) | MAP2K1 | |
| SCHEMBL2597630 | 0.66 | JAK2 (0.51) | CDK1RAF1MAP2K1 | |
| SCHEMBL31395723 | 0.65 | CDK8 (0.47) | KDREGFRABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571856-A1 | COMPOUNDS | BTG International Limited (GB) | 2013-03-27 | — | — | EP | disclosed |
| WO-2011144577-A1 | COMPOUNDS | SENEXIS LIMITED (GB) | 2011-11-24 | — | — | WO | disclosed |